Copper(II) complexes of oxytocin, 4-Glu-oxytocin, 5-Asp-oxytocin, and GlyGlyGly-Lys(8)-vasopressin were studied by potentiometric, EPR, and UV-visible spectroscopic methods. The formation of 4N-coordinated complexes was characteristic of all ligands. This type of coordination is especially favored for oxytocin due to the specific conformation of the ring coupled by the disulfide bridge. The coordination of the gamma-carboxylate group of 4-Glu-oxytocin and a disulfide sulfur atom of GlyGlyGly-Lys(8)-vasopressin was reported to occur in the 2N-complexes over medium pH range.
POTENTIOMETRIC AND SPECTROSCOPIC STUDIES ON THE COPPER(II) COMPLEXES OF PEPTIDE-HORMONES CONTAINING DISULFIDE BRIDGES / Danyi, P; Varnagy, K; Sovago, I; Schon, I; Sanna, D; Micera, Giovanni. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 60:1(1995), pp. 69-78. [10.1016/0162-0134(95)00003-7]
POTENTIOMETRIC AND SPECTROSCOPIC STUDIES ON THE COPPER(II) COMPLEXES OF PEPTIDE-HORMONES CONTAINING DISULFIDE BRIDGES
MICERA, Giovanni
1995-01-01
Abstract
Copper(II) complexes of oxytocin, 4-Glu-oxytocin, 5-Asp-oxytocin, and GlyGlyGly-Lys(8)-vasopressin were studied by potentiometric, EPR, and UV-visible spectroscopic methods. The formation of 4N-coordinated complexes was characteristic of all ligands. This type of coordination is especially favored for oxytocin due to the specific conformation of the ring coupled by the disulfide bridge. The coordination of the gamma-carboxylate group of 4-Glu-oxytocin and a disulfide sulfur atom of GlyGlyGly-Lys(8)-vasopressin was reported to occur in the 2N-complexes over medium pH range.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
