Three cases of rhabdoid tumour of the central nervous system arising in a supratentorial location are reported. The patients were 18, 14, and 7 years old. All three tumours showed a common morphology. The neoplastic cells were usually globoid with round nuclei and prominent nucleoli and large acidophilic, cytoplasmic inclusions were present in many of them. These inclusions showed strong immunoreactivity for vimentin, weak immunoreactivity for epithelial membrane antigen and focal immunoreactivity for cytokeratins. Ultrastructurally they were made up of whorls of intermediate filaments, 8-10 nm in thickness. Rhabdoid tumours of the central nervous system, whatever the cell of origin, appear to be an independent entity with identifiable histology and aggressive behaviour.
RHABDOID TUMORS OF THE CENTRAL-NERVOUS-SYSTEM - REPORT OF 3 CASES WITH IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL FINDINGS / Cossu, A; Massarelli, G; Manetto, V; Viale, G; Tanda, Francesco; Bosincu, L; Iuzzolino, P; Cossu, S; Padovani, R; Eusebi, V.. - In: VIRCHOWS ARCHIV. A, PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY. - ISSN 0174-7398. - 422:1(1993), pp. 81-85. [10.1007/BF01605137]