Arylmethyl alkyl ethers 1a-11 were metallated with n-BuLi or sec-BuLi in THF at different temperatures, affording alpha-alkoxy-substituted arylmethyllithium derivatives. At low temperature, the organometallics derived from methyl and isopropyl ethers are sufficiently stable to react with added electrophiles affording the expected products 4aa-4jb. On the contrary, under similar conditions, lithium derivatives of primary alkyl benzyl ethers rapidly decay to benzyl alcohol 3
Metalation of arylmethyl alkyl ethers / Ugo Azzena; Luciano Pilo; Alessandra Sechi. - In: TETRAHEDRON. - ISSN 0040-4020. - 54:(1998), pp. 12389-12398. [10.1016/S0040-4020(98)00758-3]
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Titolo: | Metalation of arylmethyl alkyl ethers | |
Autori: | ||
Data di pubblicazione: | 1998 | |
Rivista: | ||
Citazione: | Metalation of arylmethyl alkyl ethers / Ugo Azzena; Luciano Pilo; Alessandra Sechi. - In: TETRAHEDRON. - ISSN 0040-4020. - 54:(1998), pp. 12389-12398. [10.1016/S0040-4020(98)00758-3] | |
Handle: | http://hdl.handle.net/11388/48405 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |