1. Hemoglobin (Hb) switching in the perinatal life of wild mouflon (Ovis musimon) was characterized by the replacement of Hb F by 60% levels of Hb C, and subsequently of Hb C by Hb B. 2. The recently discovered Hb M variant was not replaced by Hb C; thus, Hb BM heterozygote newborns synthesized 30% Hb C at the expense of Hb B. 3. Hybrid B mouflon x B sheep synthesized only 5% Hb C at birth but were able to produce 30% Hb C in adult life following induced anemia. 4. Adult BB and BM mouflons, after the same extent of induced anemia, synthesized HB C levels similar to those produced at birth. The results indicate a mouflon beta-globin gene cluster arrangement similar to those of sheep and goat, the beta-c gene having an intermediate expression. Results also suggest a selective disadvantage in hybrid animals.
KINETICS OF THE ONTOGENIC AND REVERSIBLE HEMOGLOBIN SWITCHING IN THE MOUFLON (OVIS-MUSIMON) AND SHEEP X MOUFLON HYBRID / Masala, B; Manca, Laura; Cocco, E; Ledda, Sergio; Naitana, S.. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. A. COMPARATIVE PHYSIOLOGY. - ISSN 0300-9629. - 100:3(1991), pp. 675-680. [10.1016/0300-9629(91)90388-S]
KINETICS OF THE ONTOGENIC AND REVERSIBLE HEMOGLOBIN SWITCHING IN THE MOUFLON (OVIS-MUSIMON) AND SHEEP X MOUFLON HYBRID
MANCA, Laura;LEDDA, Sergio;
1991-01-01
Abstract
1. Hemoglobin (Hb) switching in the perinatal life of wild mouflon (Ovis musimon) was characterized by the replacement of Hb F by 60% levels of Hb C, and subsequently of Hb C by Hb B. 2. The recently discovered Hb M variant was not replaced by Hb C; thus, Hb BM heterozygote newborns synthesized 30% Hb C at the expense of Hb B. 3. Hybrid B mouflon x B sheep synthesized only 5% Hb C at birth but were able to produce 30% Hb C in adult life following induced anemia. 4. Adult BB and BM mouflons, after the same extent of induced anemia, synthesized HB C levels similar to those produced at birth. The results indicate a mouflon beta-globin gene cluster arrangement similar to those of sheep and goat, the beta-c gene having an intermediate expression. Results also suggest a selective disadvantage in hybrid animals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.