Five 1-lupinyl-3R'-6R"-quinoxalin-2(1H)-ones were tested in mice for acute toxicity, explorative activity inhibition, analgesic activity and for antagonism against physostigmine, strychnine and pentylentetrazol (cardiazol). As reference compounds were used chloropromazine, morphine, atropine and diazepam respectively. All tested compounds inhibit the explorative activity and exhibit high analgesic activity. Compound (I) protects completely the animals from physostigmine toxicity, while compound (IV) antagonizes, although only slightly, all the toxicants tested.
Pharmacological activity of 1-lupinylquinoxalin-2(1H)-ones 3,6-disubstituted [ATTIVITA FARMACOLOGICA DI 1-LUPINILCHINOSSALIN-2(1H)-ONI 3,6-DISOSTITUITI] / Satta, M; Peana, Alessandra Tiziana; Sparatore, A; Alamanni, Mc. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 41:9(1986), pp. 722-728.
Pharmacological activity of 1-lupinylquinoxalin-2(1H)-ones 3,6-disubstituted [ATTIVITA FARMACOLOGICA DI 1-LUPINILCHINOSSALIN-2(1H)-ONI 3,6-DISOSTITUITI]
PEANA, Alessandra Tiziana;
1986-01-01
Abstract
Five 1-lupinyl-3R'-6R"-quinoxalin-2(1H)-ones were tested in mice for acute toxicity, explorative activity inhibition, analgesic activity and for antagonism against physostigmine, strychnine and pentylentetrazol (cardiazol). As reference compounds were used chloropromazine, morphine, atropine and diazepam respectively. All tested compounds inhibit the explorative activity and exhibit high analgesic activity. Compound (I) protects completely the animals from physostigmine toxicity, while compound (IV) antagonizes, although only slightly, all the toxicants tested.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
