A series of various bis(hydroxymethyl) carbamate derivatives of 7-mono- and 7,8-disubstituted- l-methyl-benzo[g]indoles was prepared in order to evaluate their cytostatic and cytotoxic activities in vitro. Compounds 2a-h showed significant tumor growth inhibition activity and were more potent than the 4,5-dihydrobenzo[g] indole analogues previously described. Compound 2a was the most active in this series, showing high activity and selectivity for some human cancer cell lines in the National Cancer Institute screen.
Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis(hydroxymethyl)-1-methyl-7- and 7,8-substituted- benzo[g]indoles / Pinna, Gerard Aime; Pirisi, Maria Antonietta; Sechi, Mario; Paglietti, G.. - In: IL FARMACO. - ISSN 0014-827X. - 53:2(1998), pp. 161-168. [10.1016/S0014-827X(97)00016-5]
Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis(hydroxymethyl)-1-methyl-7- and 7,8-substituted- benzo[g]indoles
PINNA, Gerard Aime;PIRISI, Maria Antonietta;SECHI, Mario;
1998-01-01
Abstract
A series of various bis(hydroxymethyl) carbamate derivatives of 7-mono- and 7,8-disubstituted- l-methyl-benzo[g]indoles was prepared in order to evaluate their cytostatic and cytotoxic activities in vitro. Compounds 2a-h showed significant tumor growth inhibition activity and were more potent than the 4,5-dihydrobenzo[g] indole analogues previously described. Compound 2a was the most active in this series, showing high activity and selectivity for some human cancer cell lines in the National Cancer Institute screen.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
