we have described herein a practical procedure for the simple preparation of the single-diastereomer catalysts cis-[RuCl2(Josiphos)RPyme]—also in situ— from [RuCl2(PPh3)3], Josiphos ligands, and a racemic mixture of RPyme ligands, avoiding the need for the resolution of the aminopyridine ligands. These complexes efficiently catalyze the asymmetric transfer hydrogenation of ketones with both a very high TOF (up to 70000 h1 at 60 8C)and enantioselectivity (up to 99%ee)which is due to the correctly matched diphosphane and aminopyridine ligands. Work is in progress to extend this practical approach to other metal-catalyzed asymmetric reactions.

Highly Diastereoselective Formation of Ruthenium Complexes for Efficient Catalytic Asymmetric Transfer Hydrogenation / Baratta, W; Chelucci, Giorgio Adolfo; Herdtweck, E; Magnolia, S; Siega, K; Rigo, P.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 46:40(2007), pp. 7651-7654. [10.1002/anie.200702278]

Highly Diastereoselective Formation of Ruthenium Complexes for Efficient Catalytic Asymmetric Transfer Hydrogenation

CHELUCCI, Giorgio Adolfo;
2007-01-01

Abstract

we have described herein a practical procedure for the simple preparation of the single-diastereomer catalysts cis-[RuCl2(Josiphos)RPyme]—also in situ— from [RuCl2(PPh3)3], Josiphos ligands, and a racemic mixture of RPyme ligands, avoiding the need for the resolution of the aminopyridine ligands. These complexes efficiently catalyze the asymmetric transfer hydrogenation of ketones with both a very high TOF (up to 70000 h1 at 60 8C)and enantioselectivity (up to 99%ee)which is due to the correctly matched diphosphane and aminopyridine ligands. Work is in progress to extend this practical approach to other metal-catalyzed asymmetric reactions.
2007
Highly Diastereoselective Formation of Ruthenium Complexes for Efficient Catalytic Asymmetric Transfer Hydrogenation / Baratta, W; Chelucci, Giorgio Adolfo; Herdtweck, E; Magnolia, S; Siega, K; Rigo, P.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 46:40(2007), pp. 7651-7654. [10.1002/anie.200702278]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/47587
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