In order to determine whether an alpha1-adrenergic mechanism is involved in the secretion of Growth Hormone (GH) in humans, we studied the effect of the alpha1-adrenergic-stimulating agent methoxamine on serum GH levels in twelve normal males (age range 22-32 years). Intravenous infusion of methoxamine (dose: 6 microg/kg/min; duration: 150 min) significantly reduced serum GH levels at time 120 and 150, and on integrated concentrations. These data suggest that alpha1-adrenergic receptors inhibit tonic GH secretion in humans.
Activation of alpha1-adrenoceptors inhibits growth hormone secretion in humans / Fanciulli, Giuseppe; Tomasi, Paolo; Delitala, Ap; Delitala, Giuseppe. - In: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES. - ISSN 0947-7349. - 117:9(2009), pp. 460-462. [10.1055/s-0029-1202796]
Activation of alpha1-adrenoceptors inhibits growth hormone secretion in humans
FANCIULLI, Giuseppe;TOMASI, Paolo;DELITALA AP;DELITALA, Giuseppe
2009-01-01
Abstract
In order to determine whether an alpha1-adrenergic mechanism is involved in the secretion of Growth Hormone (GH) in humans, we studied the effect of the alpha1-adrenergic-stimulating agent methoxamine on serum GH levels in twelve normal males (age range 22-32 years). Intravenous infusion of methoxamine (dose: 6 microg/kg/min; duration: 150 min) significantly reduced serum GH levels at time 120 and 150, and on integrated concentrations. These data suggest that alpha1-adrenergic receptors inhibit tonic GH secretion in humans.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
