Taking advantage of palladium peculiar ‘‘rollover” C,N cyclometallation, it is possible to promote C(3) functionalization of 6-alkyl-substituted-2,20-bipyridines. The carbonylation reaction of rollover species [Pd(Ln)Cl]2, (HL1 = 6-isopropyl-2,20-bipy, 1; HL2 = 6-neopentyl-2,20-bipy, 2; HL3 = 6-ethyl-2,20-bipy, 3; HL4 = 6-methyl-2,20-bipy, 4) allowed the synthesis of 2-(pyridin-2-yl)-6-alkyl-nicotinic acids or esters. These nicotinic derivatives are extremely rare and, as far as we know, quite unreported in the case of the 6-substituted molecules.
Step by step palladium mediated syntheses of new 2-(pyridin-2-yl)-6-R-nicotinic acids and esters RID D-3096-2011 / Petretto, Giacomo Luigi; Zucca, Antonio; Stoccoro, Sergio; Cinellu, Maria Agostina; Minghetti, G.. - In: JOURNAL OF ORGANOMETALLIC CHEMISTRY. - ISSN 0022-328X. - 695:2(2010), pp. 7.256-7.259. [10.1016/j.jorganchem.2009.10.002]
Step by step palladium mediated syntheses of new 2-(pyridin-2-yl)-6-R-nicotinic acids and esters RID D-3096-2011
PETRETTO, Giacomo Luigi;ZUCCA, Antonio;STOCCORO, Sergio;CINELLU, Maria Agostina;
2010-01-01
Abstract
Taking advantage of palladium peculiar ‘‘rollover” C,N cyclometallation, it is possible to promote C(3) functionalization of 6-alkyl-substituted-2,20-bipyridines. The carbonylation reaction of rollover species [Pd(Ln)Cl]2, (HL1 = 6-isopropyl-2,20-bipy, 1; HL2 = 6-neopentyl-2,20-bipy, 2; HL3 = 6-ethyl-2,20-bipy, 3; HL4 = 6-methyl-2,20-bipy, 4) allowed the synthesis of 2-(pyridin-2-yl)-6-alkyl-nicotinic acids or esters. These nicotinic derivatives are extremely rare and, as far as we know, quite unreported in the case of the 6-substituted molecules.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
