Objective: The roleofinflammatoryadipokineshasclearmechanisticeffectsinthepromotionofbothDM2 and cardiovasculardiseases(CVDs),butitisunknowntowhatextentatherosclerosis-relatedinflamma- tion mightpromotedefectsofglucosemetabolism.Thepurposeofthisstudywastotestthehypothesis that insubjectswithatheroscleroticvasculardiseaseandnopreviousmedicalrecordoftype2diabetes mellitus (DM2),thediagnosisofoccultimpairedglucoseregulation(IGR)isrelatedtotheseverityof atherosclerosis, measuredasthesingleorcombinedpresenceofanhistoryofcoronaryarterydisease (CAD), carotidatherosclerosis(Car-ATS)andperipheralarterydisease(PAD). Methods: In apopulationof551subjects(440menand111women)withaprevioushistoryofatheroscle- rosis, weinvestigatedthepresenceofIGR(includingbothimpairedglucosetoleranceandDM2).Totest the correlationbetweenconventionalandnon-conventionalriskfactorsforcardiovasculardiseaseand diabetes weusedlogisticandregressionanalysismodels. Results: IGR wasmoreprevalentinpatientswithadocumentedvasculardiseaseintwoorthreevessel districts comparedwithpatientswithonlyonesymptomaticdistrict(p = 0.016).Amongclassicriskfactors we foundthatwaistcircumferencewascorrelatedneithertoIGRnortosymptomaticvasculardisease extension. Bycontrast,adiponectinlevelwasindependentlyassociatedtovascularandglucoseregulation status (p = 0.012and p < 0.001,respectively). Conclusion: In subjectsaffectedbyatheroscleroticvasculardiseases,thepresenceofimpairedglucose regulation isassociatedtothenumberofvasculardistrictsaffectedandtoareducedadiponectinlevel.
Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation / Rizza, S; Cardellini, M; Martelli, Eugenio; Porzio, O; Pecchioli, C; Nicolucci, A; Marx, N; Lauro, D; Ippoliti, A; Romeo, F; Lauro, R; Federici, M.. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 212(1):(2010), pp. 316-320.
Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation
MARTELLI, Eugenio;
2010-01-01
Abstract
Objective: The roleofinflammatoryadipokineshasclearmechanisticeffectsinthepromotionofbothDM2 and cardiovasculardiseases(CVDs),butitisunknowntowhatextentatherosclerosis-relatedinflamma- tion mightpromotedefectsofglucosemetabolism.Thepurposeofthisstudywastotestthehypothesis that insubjectswithatheroscleroticvasculardiseaseandnopreviousmedicalrecordoftype2diabetes mellitus (DM2),thediagnosisofoccultimpairedglucoseregulation(IGR)isrelatedtotheseverityof atherosclerosis, measuredasthesingleorcombinedpresenceofanhistoryofcoronaryarterydisease (CAD), carotidatherosclerosis(Car-ATS)andperipheralarterydisease(PAD). Methods: In apopulationof551subjects(440menand111women)withaprevioushistoryofatheroscle- rosis, weinvestigatedthepresenceofIGR(includingbothimpairedglucosetoleranceandDM2).Totest the correlationbetweenconventionalandnon-conventionalriskfactorsforcardiovasculardiseaseand diabetes weusedlogisticandregressionanalysismodels. Results: IGR wasmoreprevalentinpatientswithadocumentedvasculardiseaseintwoorthreevessel districts comparedwithpatientswithonlyonesymptomaticdistrict(p = 0.016).Amongclassicriskfactors we foundthatwaistcircumferencewascorrelatedneithertoIGRnortosymptomaticvasculardisease extension. Bycontrast,adiponectinlevelwasindependentlyassociatedtovascularandglucoseregulation status (p = 0.012and p < 0.001,respectively). Conclusion: In subjectsaffectedbyatheroscleroticvasculardiseases,thepresenceofimpairedglucose regulation isassociatedtothenumberofvasculardistrictsaffectedandtoareducedadiponectinlevel.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
