The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization.

Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread / Santapaola, D; Del Chierico, F; Petrucca, A; Uzzau, Sergio; Casalino, M; Colonna, B; Sessa, R; Berlutti, F; Nicoletti, M.. - In: JOURNAL OF BACTERIOLOGY. - ISSN 0021-9193. - 188:4(2006), pp. 1620-1627. [10.1128/JB.188.4.1620-1627.2006]

Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread

UZZAU, Sergio;
2006-01-01

Abstract

The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization.
2006
Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread / Santapaola, D; Del Chierico, F; Petrucca, A; Uzzau, Sergio; Casalino, M; Colonna, B; Sessa, R; Berlutti, F; Nicoletti, M.. - In: JOURNAL OF BACTERIOLOGY. - ISSN 0021-9193. - 188:4(2006), pp. 1620-1627. [10.1128/JB.188.4.1620-1627.2006]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/47337
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 28
social impact