Copper(II), nickel(II) and zinc(II) complexes of the peptides GlyLys(Gly) and Asp-epsilon-Lys, containing the amide functions at the c-amino groups of the lysyl residues were studied by potentiometric, UV-VIS and EPR spectroscopic methods. The stoichiometry of the major species formed in the copper(II)-GlyLys(Gly) system is [CuH-1L] and the EPR spectroscopic data indicate the existence of two isomeric forms of the complex. The nickel(II) and zinc(II)-GlyLys(Gly) systems have been characterised by the formation of stable [ML](+) complexes containing bis(NH2,CO) co-ordination and a macrochelate. Deprotonation and co-ordination of the amide groups were detected in the copper(II) and nickel(II) complexes. The co-ordination chemistry of Asp-epsilon-Lys is best described by the metal binding ability of the amino acid residues and it's high affinity for dimerisation. The stoichiometry of the dinuclear complexes can be given as [M2L2]. containing only amino acid binding sites. Deprotonation and co-ordination of the amide functions were suggested only in the copper(II)-containing systems, resulting in the formation of the [Cu2H-2L2](2-) dinuclear complex.
Potentiometric and spectroscopic studies on transition metal complexes of GlyLys(Gly) and Asp-epsilon-Lys / Kallay, C; Varnagy, K; Sovago, I; Sanna, D; Micera, Giovanni. - In: JOURNAL OF THE CHEMICAL SOCIETY. DALTON TRANSACTIONS. - ISSN 1472-7773. - 1(2002), pp. 92-98. [10.1039/b105041a]
Potentiometric and spectroscopic studies on transition metal complexes of GlyLys(Gly) and Asp-epsilon-Lys
MICERA, Giovanni
2002-01-01
Abstract
Copper(II), nickel(II) and zinc(II) complexes of the peptides GlyLys(Gly) and Asp-epsilon-Lys, containing the amide functions at the c-amino groups of the lysyl residues were studied by potentiometric, UV-VIS and EPR spectroscopic methods. The stoichiometry of the major species formed in the copper(II)-GlyLys(Gly) system is [CuH-1L] and the EPR spectroscopic data indicate the existence of two isomeric forms of the complex. The nickel(II) and zinc(II)-GlyLys(Gly) systems have been characterised by the formation of stable [ML](+) complexes containing bis(NH2,CO) co-ordination and a macrochelate. Deprotonation and co-ordination of the amide groups were detected in the copper(II) and nickel(II) complexes. The co-ordination chemistry of Asp-epsilon-Lys is best described by the metal binding ability of the amino acid residues and it's high affinity for dimerisation. The stoichiometry of the dinuclear complexes can be given as [M2L2]. containing only amino acid binding sites. Deprotonation and co-ordination of the amide functions were suggested only in the copper(II)-containing systems, resulting in the formation of the [Cu2H-2L2](2-) dinuclear complex.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.