Rokitamycin is a new macrolide containing 16 carbon atoms, strongly inhibitory for Acanthamoeba castellanii, an opportunistic protozoa of humans which cause primarily amoebic keratitis and chronic, but fatal, amoebic granulomatous meningoencephalitis. Chitosan microspheres were prepared as carriers to obtain a controlled release of rokitamycin, able to improve the antiamoebic activity of this drug. The microparticles were in vitro characterised and the efficacy of rokitamycin alone and encapsulated into microspheres on the growth rate of Acanthamoeba castellani was evaluated. The results obtained suggest that spray-drying is a good technique for the preparation of microspheres loaded with rokitamycin. The loading of the drug into the polymeric network leads to an increase in the dissolution rate compared to drug raw material and improves and prolongs the in vitro antiamoebic activity of the drug. Thus, microspheres based on rokitamycin could be used in the therapy of systemic and topical infections caused by Acanthamoeba.
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|Titolo:||Improvement of antiamoebic activity of rokitamycin loaded in chitosan microspheres|
|Autori interni:||MATTANA, Antonella|
|Data di pubblicazione:||2008|
|Rivista:||THE OPEN DRUG DELIVERY JOURNAL|
|Appare nelle tipologie:||1.1 Articolo in rivista|