This work was undertaken to determine whether Acanthamoeba could play a role in the survival and transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and their transmission to human hosts.
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|Titolo:||Acanthamoeba castellanii promotion of the in vitro survival and transmission of Coxsackie-B-3 viruses|
|Autori interni:||SERRA, Caterina|
FIORI, Pier Luigi
|Data di pubblicazione:||2006|
|Appare nelle tipologie:||1.1 Articolo in rivista|