Cystic Echinococcosis (CE) is an infective zoonosis that represents a worldwide important public health problem. In humans, its manifestations may range from asymptomatic infection to severe disease and possible death, and lead also to economic losses from treatment costs and lost wages. Recent studies suggest that this disease has a large social impact on endemic areas, and estimates of burden in terms of monetary and no-monetary impact on human health are essential to allocate financial and technical resources. In Sardinia, the most affected Italian region per number of inhabitants, CE is still endemic, although three eradication campaigns have been carried out in 1962, 1978, and 1987, respectively. To date, the burden of human CE in Sardinia remains poorly defined. In this work, a retrospective study was carried out using public Hospital Discharge Records drawn from the regional database between 2001 and 2009. During these years, a total of 1409 discharges were recorded, 1196 (84.88%) records corresponding to primary diagnosis, that is, patients hospitalized for symptoms directly correlated to CE (occurrence of disease), and 213 (15.11%) records corresponding to secondary diagnosis, that is, patients hospitalized for symptoms not directly correlated to CE and with an afterwards or concurrent diagnosis of echinococcosis made during the hospitalization (occurrence of infection), with an annual regional average record of 9.5 per 100,000 inhabitants. Direct cost associated with diagnosis, surgery or chemotherapy, medical care, and hospitalization in humans were evaluated in this work. Furthermore, indirect costs were also evaluated by using the disability-adjusted life years (DALYs), the preferred disease-burden measure of the World Health Organization. The purpose of this study was to estimate the burden of human CE in Sardinia. Such an estimate is imperative since it can be used as a tool to prioritize control measures for this essentially preventable neglected disease.
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|Titolo:||A retrospective study on burden of human echinococcosis based on Hospital Discharge Records from 2001 to 2009 in Sardinia, Italy|
|Data di pubblicazione:||2012|
|Appare nelle tipologie:||1.1 Articolo in rivista|