•Continuing our program of research concerning the antiviral activity of a wide series of new angular and •linear azolo bicyclic and tricyclic derivatives, now we have simpliﬁed and modiﬁed the 4-chloro-2-(4nitrophenyl)-3H-imidazo[4,5-g]quinoline 1, which previously resulted the most active derivative, through either the elimination of the central ring or the opening of the imidazole ring,obtaining various imidazopyridines and N-benzylidenequinolinamines respectively. Title compounds were tested in cell-based assays for cytotoxicity and antiviral activity against representatives of two DNA virus families as wells as against representatives of RNA virus families containingsingle-stranded,eitherpositive-sense(ssRNAþ)ornegative-sense(ssRNA),anddouble-stranded genomes (dsRNA). Some imidazo[4,5-b]pyridines emerged as new derivatives endowed with antiviral activity against Vaccinia Virus (VV) at concentrations ranging from 2 to 16 mM. In particular, compound 2b demonstrate to be about 10 times more potent than Cidofovir, used as reference drug. Similarly, the imidazo[4,5-c]pyridines and N-benzylidenequinolinamines derivatives resulted active against Bovine Viral Diarrhoea virus (BVDV), at concentrations ranging from 1.2 to 28 mM. Above all compounds 1, 3a and 3f showed an EC50 of the same order of magnitude of the reference drug,the20-C-methyl-guanosine. Moreover, several N-benzylidenequinolinamines showed an interesting activity against Respiratory Syncytial Virus (RSV) at concentrations between 12 and 26 mM.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
|Titolo:||Synthesis and antiviral activity of new phenylimidazopyridines and N-benzylidenequinolinamines derived by molecular simplification of phenylimidazo[4,5-g]quinolines|
|Autori interni:||CORONA, Paola|
|Data di pubblicazione:||2014|
|Rivista:||EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY|
|Appare nelle tipologie:||1.1 Articolo in rivista|