Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.

Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis / Molicotti, Paola; Bua, Alessandra; Cubeddu, Marina; Cannas, Sara; Delogu, G; Zanetti, Stefania Anna Lucia. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 71:4(2011), pp. 449-452. [10.1016/j.diagmicrobio.2011.08.010]

Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis

MOLICOTTI, Paola;BUA, Alessandra;CUBEDDU, Marina;CANNAS, Sara;ZANETTI, Stefania Anna Lucia
2011-01-01

Abstract

Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-α secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-α. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.
2011
Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis / Molicotti, Paola; Bua, Alessandra; Cubeddu, Marina; Cannas, Sara; Delogu, G; Zanetti, Stefania Anna Lucia. - In: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. - ISSN 0732-8893. - 71:4(2011), pp. 449-452. [10.1016/j.diagmicrobio.2011.08.010]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/45682
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