The in vitro sensitivity of nine Trichomonas vaginalis isolates to commonly employed 5-nitroimidazoles (metronidazole, nimorazole, ornidazole and tinidazole) was evaluated in absence and in presence of sub-inhibitory concentrations of hydrogen peroxide (H2O2). Co-incubation with H2O2 and 5-nitroimidazole compounds decreased the MIC values of the strains exhibiting cross-resistance to these drugs. It was suggested that H2O2 produced in the inflammatory process during trichomonal infection could enhance the therapeutic effect of 5-nitroimidazole drugs.
Enhancement of the antitrichomonal activity of 5-nitroimidazole derivatives by hydrogen peroxide / Mattana, Antonella; Juliano, Claudia Clelia Assunta; V., Picci; F., Franconi; P., Cappuccinelli. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 16:4(1993), pp. 359-365.
Enhancement of the antitrichomonal activity of 5-nitroimidazole derivatives by hydrogen peroxide
MATTANA, Antonella;JULIANO, Claudia Clelia Assunta;
1993-01-01
Abstract
The in vitro sensitivity of nine Trichomonas vaginalis isolates to commonly employed 5-nitroimidazoles (metronidazole, nimorazole, ornidazole and tinidazole) was evaluated in absence and in presence of sub-inhibitory concentrations of hydrogen peroxide (H2O2). Co-incubation with H2O2 and 5-nitroimidazole compounds decreased the MIC values of the strains exhibiting cross-resistance to these drugs. It was suggested that H2O2 produced in the inflammatory process during trichomonal infection could enhance the therapeutic effect of 5-nitroimidazole drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
