The association between exposure to toxic metals and amyotrophic lateral sclerosis (ALS) was explored in a population-based case-control study in the Sardinia island (Italy), a region characterized by elevated rates of ALS cases. In 34 patients with ALS (mean age, 62±10years) and 30 controls (mean age, 65±11years), Al, Cd, Hg, Mn and Pb were determined in blood, hair and urine by sector field inductively coupled mass spectrometry. Results indicated that, in blood, concentrations of Al (p=0.045) and Pb were higher (p=0.026) in ALS patients than in control subjects. In hair, a depletion of Al (p=0.006) and Mn (p=0.032) concentrations in ALS subjects respect to controls was found. In urine, no significant differences between cases and controls were observed. Thus, some metals seemed to be associated with ALS degeneration, but a definitive conclusion is still far considering the multiple risk factors (genetic mutations, environmental toxicants and stressors) involved in the disease. Finally, the interpretation that deregulated metal concentrations can be a consequence of the degenerative process, rather than a cause, is also valid

Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case-control study / Bocca, B; Forte, G; Oggiano, R; Clemente, S; Asara, Y; Peruzzu, A; Farace, C; Pala, S; Fois, Alessandro Giuseppe; Pirina, Pietro; Madeddu, Roberto Beniamino. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 359:(2015), pp. 11-17. [10.1016/j.jns.2015.10.023]

Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case-control study

Farace C;FOIS, Alessandro Giuseppe;PIRINA, Pietro;MADEDDU, Roberto Beniamino
2015-01-01

Abstract

The association between exposure to toxic metals and amyotrophic lateral sclerosis (ALS) was explored in a population-based case-control study in the Sardinia island (Italy), a region characterized by elevated rates of ALS cases. In 34 patients with ALS (mean age, 62±10years) and 30 controls (mean age, 65±11years), Al, Cd, Hg, Mn and Pb were determined in blood, hair and urine by sector field inductively coupled mass spectrometry. Results indicated that, in blood, concentrations of Al (p=0.045) and Pb were higher (p=0.026) in ALS patients than in control subjects. In hair, a depletion of Al (p=0.006) and Mn (p=0.032) concentrations in ALS subjects respect to controls was found. In urine, no significant differences between cases and controls were observed. Thus, some metals seemed to be associated with ALS degeneration, but a definitive conclusion is still far considering the multiple risk factors (genetic mutations, environmental toxicants and stressors) involved in the disease. Finally, the interpretation that deregulated metal concentrations can be a consequence of the degenerative process, rather than a cause, is also valid
2015
Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case-control study / Bocca, B; Forte, G; Oggiano, R; Clemente, S; Asara, Y; Peruzzu, A; Farace, C; Pala, S; Fois, Alessandro Giuseppe; Pirina, Pietro; Madeddu, Roberto Beniamino. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 359:(2015), pp. 11-17. [10.1016/j.jns.2015.10.023]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/45405
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 43
  • ???jsp.display-item.citation.isi??? 40
social impact