Objectives: To investigate the relationship between amyotrophic lateral sclerosis (ALS) and cognitive function by means of oddball event-related potentials (ERPs) and to determine the usefulness of this methodology in the cognitive status assessment of physically disabled patients. Methods: Visual and auditory oddball ERPs were recorded in 16 consecutive sporadic ALS patients. A comprehensive battery of neuropsychological (NP) tests assessed intelligence, executive functions, attention, memory, word ﬂuency, visuo-motor and visual-constructive skills. Results: All patients performed visual and auditory ERPs and 75% of cases showed abnormal N200 and/or P300 waves. Ten patients (62.5%) carried out the entire psychometric evaluation with signiﬁcant impairment on tests of executive function and attention. A signiﬁcant correlation between delayed visual ðP , 0:04Þ and auditory ðP , 0:04Þ P300 latency and impaired NP tests was found. Conclusions: In agreement with literature data, our ﬁndings conﬁrm the hypothesis of cognitive impairment in ALS patients especially on attention and executive functions suggesting a more extensive degeneration beyond the motor areas. ALS causes severe physical disabilities and such a condition may interfere with NP testing. Thus, the P300 seems to be a useful tool for the assessment of cognition and attention when severe physical deﬁcits are present. q 2002 Elsevier Science Ireland Ltd. All rights reserved
Visual and auditory event-related potentials in sporadic amyotrophic lateral sclerosis / Paulus, Ks; Magnano, I; Piras, Maria Rita; Solinas, Maria Giuliana; Solinas, G; Sau, Gf; Aiello, Isidoro Cesare Giuseppe. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 113:(2002), pp. 853-861.