Objectives: To investigate the relationship between amyotrophic lateral sclerosis (ALS) and cognitive function by means of oddball event-related potentials (ERPs) and to determine the usefulness of this methodology in the cognitive status assessment of physically disabled patients. Methods: Visual and auditory oddball ERPs were recorded in 16 consecutive sporadic ALS patients. A comprehensive battery of neuropsychological (NP) tests assessed intelligence, executive functions, attention, memory, word fluency, visuo-motor and visual-constructive skills. Results: All patients performed visual and auditory ERPs and 75% of cases showed abnormal N200 and/or P300 waves. Ten patients (62.5%) carried out the entire psychometric evaluation with significant impairment on tests of executive function and attention. A significant correlation between delayed visual ðP , 0:04Þ and auditory ðP , 0:04Þ P300 latency and impaired NP tests was found. Conclusions: In agreement with literature data, our findings confirm the hypothesis of cognitive impairment in ALS patients especially on attention and executive functions suggesting a more extensive degeneration beyond the motor areas. ALS causes severe physical disabilities and such a condition may interfere with NP testing. Thus, the P300 seems to be a useful tool for the assessment of cognition and attention when severe physical deficits are present. q 2002 Elsevier Science Ireland Ltd. All rights reserved

Visual and auditory event-related potentials in sporadic amyotrophic lateral sclerosis / Paulus, Ks; Magnano, I; Piras, Maria Rita; Solinas, Maria Giuliana; Solinas, G; Sau, Gf; Aiello, Isidoro Cesare Giuseppe. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 113:(2002), pp. 853-861.

Visual and auditory event-related potentials in sporadic amyotrophic lateral sclerosis

PIRAS, Maria Rita;SOLINAS, Maria Giuliana;AIELLO, Isidoro Cesare Giuseppe
2002

Abstract

Objectives: To investigate the relationship between amyotrophic lateral sclerosis (ALS) and cognitive function by means of oddball event-related potentials (ERPs) and to determine the usefulness of this methodology in the cognitive status assessment of physically disabled patients. Methods: Visual and auditory oddball ERPs were recorded in 16 consecutive sporadic ALS patients. A comprehensive battery of neuropsychological (NP) tests assessed intelligence, executive functions, attention, memory, word fluency, visuo-motor and visual-constructive skills. Results: All patients performed visual and auditory ERPs and 75% of cases showed abnormal N200 and/or P300 waves. Ten patients (62.5%) carried out the entire psychometric evaluation with significant impairment on tests of executive function and attention. A significant correlation between delayed visual ðP , 0:04Þ and auditory ðP , 0:04Þ P300 latency and impaired NP tests was found. Conclusions: In agreement with literature data, our findings confirm the hypothesis of cognitive impairment in ALS patients especially on attention and executive functions suggesting a more extensive degeneration beyond the motor areas. ALS causes severe physical disabilities and such a condition may interfere with NP testing. Thus, the P300 seems to be a useful tool for the assessment of cognition and attention when severe physical deficits are present. q 2002 Elsevier Science Ireland Ltd. All rights reserved
Visual and auditory event-related potentials in sporadic amyotrophic lateral sclerosis / Paulus, Ks; Magnano, I; Piras, Maria Rita; Solinas, Maria Giuliana; Solinas, G; Sau, Gf; Aiello, Isidoro Cesare Giuseppe. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 113:(2002), pp. 853-861.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/45297
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