On the ground of the evidentiated choleretic activity of 3-[2- benzylbenzimidazol-1-yl]butanoic acid, 28 new acids were prepared in order to evaluate the influence of suitable substitutions in either C5 of heteroring or C3', C4', C5' of benzyl group in position 2 on the choleretic activity. Pharmacological results after i.v. administration of 0.5 mmol/Kg in rats confirmed a general high choleretic activity that in eleven cases showed during the first 4 hours an increase of bile volume higher than 80%, that is superior to that produced by dehydrocholic acid. Only in a few cases the bile volume increase was less than 37% of basal value.
Synthesis and choleretic activity of 3-[2-(3-R', 4-R'', 5R'''-Benzyl)-5-R-Benzimidazol-1-YL]- Butanoic acids / G., Grella; G., Paglietti; F., Sparatore; M., Satta; P., Manca; Peana, Alessandra Tiziana. - In: IL FARMACO. - ISSN 0014-827X. - 47:1(1992), pp. 21-35.
Synthesis and choleretic activity of 3-[2-(3-R', 4-R'', 5R'''-Benzyl)-5-R-Benzimidazol-1-YL]- Butanoic acids
PEANA, Alessandra Tiziana
1992-01-01
Abstract
On the ground of the evidentiated choleretic activity of 3-[2- benzylbenzimidazol-1-yl]butanoic acid, 28 new acids were prepared in order to evaluate the influence of suitable substitutions in either C5 of heteroring or C3', C4', C5' of benzyl group in position 2 on the choleretic activity. Pharmacological results after i.v. administration of 0.5 mmol/Kg in rats confirmed a general high choleretic activity that in eleven cases showed during the first 4 hours an increase of bile volume higher than 80%, that is superior to that produced by dehydrocholic acid. Only in a few cases the bile volume increase was less than 37% of basal value.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
