Reduction of 1,2-diaryl-substituted ethenes with Na metal in dry THF allowed easy access to a variety of 1,2-diaryl-1,2- disodiumethanes. These diorganometallic intermediates were elaborated into the corresponding 1,2-diarylethanes (aqueous work up), or cycloalkylated with 1,3-dichloropropanes. The last reaction led to a highly diastereoselective synthesis of trans-1,2-diaryl-substituted cyclopentanes.

Reduction of 1,2-diaryl-substituted ethenes with Na metal in dry THF allowed easy access to a variety of 1,2-diaryl-1,2-disodiumethanes. These diorganometallic intermediates were elaborated into the corresponding 1,2-diarylethanes (aqueous work up), or cycloalkylated with 1,3-dichloropropanes. The last reaction led to a highly diastereoselective synthesis of trans-1,2-diaryl-substituted cyclopentanes. (c) 2005 Elsevier Ltd. All rights reserved

Reductive Metalationof 1,2-Diaryl-substituted Ethenes: Synthetic Applications / Azzena, Ugo Gavino; Dettori, G; Lubinu, C; Mannu, A; Pisano, Luisa. - In: TETRAHEDRON. - ISSN 0040-4020. - 61:36(2005), pp. 8663-8669.

Reductive Metalationof 1,2-Diaryl-substituted Ethenes: Synthetic Applications

AZZENA, Ugo Gavino;PISANO, Luisa
2005-01-01

Abstract

Reduction of 1,2-diaryl-substituted ethenes with Na metal in dry THF allowed easy access to a variety of 1,2-diaryl-1,2- disodiumethanes. These diorganometallic intermediates were elaborated into the corresponding 1,2-diarylethanes (aqueous work up), or cycloalkylated with 1,3-dichloropropanes. The last reaction led to a highly diastereoselective synthesis of trans-1,2-diaryl-substituted cyclopentanes.
2005
Reduction of 1,2-diaryl-substituted ethenes with Na metal in dry THF allowed easy access to a variety of 1,2-diaryl-1,2-disodiumethanes. These diorganometallic intermediates were elaborated into the corresponding 1,2-diarylethanes (aqueous work up), or cycloalkylated with 1,3-dichloropropanes. The last reaction led to a highly diastereoselective synthesis of trans-1,2-diaryl-substituted cyclopentanes. (c) 2005 Elsevier Ltd. All rights reserved
Reductive Metalationof 1,2-Diaryl-substituted Ethenes: Synthetic Applications / Azzena, Ugo Gavino; Dettori, G; Lubinu, C; Mannu, A; Pisano, Luisa. - In: TETRAHEDRON. - ISSN 0040-4020. - 61:36(2005), pp. 8663-8669.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/44935
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