Background and study aim: The aim of this study was to assess the prevalence of nonpolypoid lesions (NPLs) in Italy and their risk of containing neoplasia or advanced histology. Patients and methods: This was a multicenter cross-sectional observational study on consecutive patients undergoing total colonoscopy over a 3-month period in 80 Italian centers. Results: In all, 27,400 total colonoscopies were analyzed. Cancer was diagnosed in 801 patients (2.9 %). A total of 6553 precancerous lesions were detected in 5609 patients. Of these, 4154 patients (74.1 %) had polypoid lesions and 1455 patients (25.9 %) had NPLs. Therefore, the prevalence of NPLs was 5.3 % (95 %CI 5.0 - 5.6). NPLs larger than 10 mm were detected in 254 patients (17.5 %). NPLs were more predominant in the proximal colon (OR 2.92, 95 %CI 2.56 - 3.43; P < 0.0001 vs. polypoid lesions). Neoplastic tissue was diagnosed in 79.0 % and advanced histology (high-grade intraepithelial neoplasia or more) in 20.9 % of resected lesions. The risk of advanced histology was similar for polypoid and nonpolypoid lesions when adjusted for size. Depressed lesions had the highest risk of advanced histology (OR 10.56, 95 %CI 6.02 - 18.55; P < 0.0000 vs. flat-elevated). Age was an independent predictor of both neoplasia and advanced histology ( P = 0.0001). Conclusions: NPLs are relatively common in the Italian population, with a prevalence similar to that in other Western series. NPLs are not more aggressive than polypoid lesions, except for those with depressed morphology.
Prevalence of nonpolypoid colorectal neoplasia: an Italian multicenter observational study / M. A., Bianco; L., Cipolletta; G., Rotondano; F., Buffoli; G., Gizzi; Tessari, ; Crotta, S; Strini, G; Orsello, M; Ballare, M; Gallo, M; Salacone, P; Asnaghi, G; Manca, A; Rizzi, R; Predebon, S; Quattrone, P; Vanni, R; Di Placido, R; Bastardini, R; V Cristoni, M; Praiano, F; Meroni, E; Fasoli, A; Coccia, G; Allegretti, A; Manes, G; Cesari, P; Rolfi, F; Zambelli, A; Manfredi, G; Lisi, S; Cestari, R; P Lancini, G; Crosta, C; Fiori, G; De Roberto, G; Dal Fante, M; Fazzini, L; Dinelli, M; Frego, R; Parente, F; Bargiggia, S; Paggi, S; Viale, E; A Testoni, P; Buffoli, F; Iiritano, E; Andrian, G; Dinca, M; Germana, B; Lecis, P; Cappiello, R; Sablich, R; Tonello, C; Buri, L; Cannizzaro, R; Maiero, S; Fasoli, R; Ceroni, L; H Eusebi, L; Iori, V; Tioli, C; Villani, V; Cortini, C; Maltoni, S; Forti, E; Solmi, L; Giovanardi, M; Calella, F; Tarantino, O; Widmayer, C; Silvestrelli, M; Bou Serhal, T; Feliciangeli, G; Tombesi, G; Anti, M; Pastorelli, A; Costamagna, G; Petruzziello, L; Cesaro, P; De Masi, E; Errico, A; Di Giulio, E; Carnuccio, A; Gabbrielli, A; Pandolfi, M; Lamazza, A; Femia, S; Morini, S; Lorenzetti, R; Del Vecchio Blanco, G; Grasso, E; Ferrara, M; Apuzzo, M; Iacopini, F; Milano, A; Balatsinou, C; Spadaccini, A; Silla, M; Ingrosso, M; A Pirozzi, G; De Luca, L; De Bellis, M; Tempesta, A; D De Palma, G; Siciliano, S; Di Giorgio, P; Giannattasio, F; Galloro, G; Grimaldi, E; Ciarleglio, A; Sarrantonio, G; Delle Cave, M; Lamanda, R; De Stefano, S; Labianca, O; Maisto, T; Montanaro, F; Pasquale, L; Di Girolamo, E; Piscopo, R; De Seta, M; Romano, M; Borgheresi, P; Romano, M; G Gravina, A; Sarracco, P; Scaglione, G; Marmo, R; Salerno, R; Gentile, M; Annese, V; Della Valle, N; Muscatiello, N; Di Matteo, G; Giorgio, P; Fregola, G; Quatraro, F; Pisani, A; Tonti, P; Stoppino, G; Corazza, L; D'Ascoli, B; Ciuffi, M; Ignomirelli, O; Giglio, A; Rodino, S; M Scanu, A; Loriga, P; Murgia, R; Giacobbe, G; Grande, D; Montalbano, L; Linea, C. - In: ENDOSCOPY. - ISSN 0013-726X. - 42:4(2010), pp. 279-285. [10.1055/s-0029-1244020]
Prevalence of nonpolypoid colorectal neoplasia: an Italian multicenter observational study
A M ScanuMembro del Collaboration Group
;
2010-01-01
Abstract
Background and study aim: The aim of this study was to assess the prevalence of nonpolypoid lesions (NPLs) in Italy and their risk of containing neoplasia or advanced histology. Patients and methods: This was a multicenter cross-sectional observational study on consecutive patients undergoing total colonoscopy over a 3-month period in 80 Italian centers. Results: In all, 27,400 total colonoscopies were analyzed. Cancer was diagnosed in 801 patients (2.9 %). A total of 6553 precancerous lesions were detected in 5609 patients. Of these, 4154 patients (74.1 %) had polypoid lesions and 1455 patients (25.9 %) had NPLs. Therefore, the prevalence of NPLs was 5.3 % (95 %CI 5.0 - 5.6). NPLs larger than 10 mm were detected in 254 patients (17.5 %). NPLs were more predominant in the proximal colon (OR 2.92, 95 %CI 2.56 - 3.43; P < 0.0001 vs. polypoid lesions). Neoplastic tissue was diagnosed in 79.0 % and advanced histology (high-grade intraepithelial neoplasia or more) in 20.9 % of resected lesions. The risk of advanced histology was similar for polypoid and nonpolypoid lesions when adjusted for size. Depressed lesions had the highest risk of advanced histology (OR 10.56, 95 %CI 6.02 - 18.55; P < 0.0000 vs. flat-elevated). Age was an independent predictor of both neoplasia and advanced histology ( P = 0.0001). Conclusions: NPLs are relatively common in the Italian population, with a prevalence similar to that in other Western series. NPLs are not more aggressive than polypoid lesions, except for those with depressed morphology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
