Purpose: To assess changes of cardiovascular risk scores and metabolic scores after switching to DOR/3TC/TDF (DOR group), DTG/3TC (DTG group) or BIC/FTC/TAF (BIC group). Method: We analyzed data from a multicenter cohort of 1069 virologically-suppressed PWH, collecting clinical history and laboratory parameters at baseline and 48 weeks of follow-up. In eligible PWH we calculated Body Mass Index (BMI), SCORE-2 and METS-IR at both timepoints and performed linear mixed model for repeated measures to measure changes in parameters, while using linear regression analyses to search for predictors of change. Results: Population characteristics are shown in table below. After 48 weeks, we observed significant changes in median SCORE-2 in all groups: there were increases of +0.12 in the DTG group (p=0.021) and +0.30 in the BIC group (<0.001), while we observed a decrease of -0.35 in the DOR group (p<0.001). In our regression analyses, taking DOR/3TC/TDF was a predictor of reduction of SCORE-2 at week 48 compared with both DTG (B=- 0.80,p<0.001) and BIC (B=-0.81,p<0.001). Moreover, a higher SCORE-2 at baseline predicted a more pronounced improvement after 48 weeks in the DOR group (B=-0.33,p<0.001), while there were no predictors in the BIC and DTG groups. Regarding BMI, after 48 weeks we observed a median increase of +0.2 in BIC (p<0.001), no changes in the DTG group and a median decrease of -0.04 in the DOR group (p<0.001). In our regression analyses, taking DOR/3TC/TDF was a predictor of reduction of BMI at week 48 compared with both DTG (B=-0.53,p<0.001) and BIC (B=-0.51,p<0.001). Finally, regarding METS-IR, after 48 weeks we observed a significant decrease in the DOR group (-0.9, p=0.024), while there were no significant changes with DTG and an increase of +0.3 with BIC (p=0.013). Conclusions: We found that switching to DOR/3TC/ TDF was associated with more favorable changes in SCORE-2, METS-IR and BMI compared to DTG/3TC and BIC/FTC/TAF.
Changes in cardiovascular and metabolic risk scores after switching to DOR/3TC/TDF, DTG/3TC or BIC/FTC/TAF: results from a multicenter Italian cohort / Ciccullo, Arturo; Iannone, Valentina; Giacomelli, Andrea; Baldin, Gianmaria; Lagi, Filippo; Sambo, Margherita; Fabbiani, Massiminilano; Borghetti, Alaberto; Francisci, Daniela; Madeddu, Giordano; Mussini, Cristina; Antinori, Spinello; Di Giambenedetto, Simona. - In: HIV MEDICINE. - ISSN 1468-1293. - (2025), pp. 196-197. [10.1111/hiv.70104]
Changes in cardiovascular and metabolic risk scores after switching to DOR/3TC/TDF, DTG/3TC or BIC/FTC/TAF: results from a multicenter Italian cohort
Giordano Madeddu;
2025-01-01
Abstract
Purpose: To assess changes of cardiovascular risk scores and metabolic scores after switching to DOR/3TC/TDF (DOR group), DTG/3TC (DTG group) or BIC/FTC/TAF (BIC group). Method: We analyzed data from a multicenter cohort of 1069 virologically-suppressed PWH, collecting clinical history and laboratory parameters at baseline and 48 weeks of follow-up. In eligible PWH we calculated Body Mass Index (BMI), SCORE-2 and METS-IR at both timepoints and performed linear mixed model for repeated measures to measure changes in parameters, while using linear regression analyses to search for predictors of change. Results: Population characteristics are shown in table below. After 48 weeks, we observed significant changes in median SCORE-2 in all groups: there were increases of +0.12 in the DTG group (p=0.021) and +0.30 in the BIC group (<0.001), while we observed a decrease of -0.35 in the DOR group (p<0.001). In our regression analyses, taking DOR/3TC/TDF was a predictor of reduction of SCORE-2 at week 48 compared with both DTG (B=- 0.80,p<0.001) and BIC (B=-0.81,p<0.001). Moreover, a higher SCORE-2 at baseline predicted a more pronounced improvement after 48 weeks in the DOR group (B=-0.33,p<0.001), while there were no predictors in the BIC and DTG groups. Regarding BMI, after 48 weeks we observed a median increase of +0.2 in BIC (p<0.001), no changes in the DTG group and a median decrease of -0.04 in the DOR group (p<0.001). In our regression analyses, taking DOR/3TC/TDF was a predictor of reduction of BMI at week 48 compared with both DTG (B=-0.53,p<0.001) and BIC (B=-0.51,p<0.001). Finally, regarding METS-IR, after 48 weeks we observed a significant decrease in the DOR group (-0.9, p=0.024), while there were no significant changes with DTG and an increase of +0.3 with BIC (p=0.013). Conclusions: We found that switching to DOR/3TC/ TDF was associated with more favorable changes in SCORE-2, METS-IR and BMI compared to DTG/3TC and BIC/FTC/TAF.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
