Crystals of the model protein lysozyme were grown and soaked with the potential drug VIVO(acetylacetonato)2 at 37°C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature.
Formation of Mixed‐Valence Cage‐Like Polyoxidovanadates at 37°C Upon Reaction of VIVO(acetylacetonato)2 With Lysozyme / Tito, Gabriella; Ferraro, Giarita; Garribba, Eugenio; Merlino, Antonello. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 31:32(2025), p. e202500488. [10.1002/chem.202500488]
Formation of Mixed‐Valence Cage‐Like Polyoxidovanadates at 37°C Upon Reaction of VIVO(acetylacetonato)2 With Lysozyme
Garribba, Eugenio
;Merlino, Antonello
2025-01-01
Abstract
Crystals of the model protein lysozyme were grown and soaked with the potential drug VIVO(acetylacetonato)2 at 37°C. X-ray diffraction and electron paramagnetic resonance (EPR) data collected at this temperature reveal that mixed-valence cage-like polyoxidovanadate clusters are formed and covalently bind protein residue side chains at physiological temperature.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
