Introduction Flexible bronchoscopy (FB) is widely used for diagnostic and therapeutic procedures in pulmonary medicine. However, FB can cause respiratory and haemodynamic complications, especially in patients with pre-existing lung and/or cardiovascular comorbidities. Despite the range of oxygenation and ventilatory approaches available to prevent these risks, evidence regarding their real-world application and clinical impact is limited. The OxyFOB study aims to assess the prevalence and outcomes of various oxygenation and ventilatory support strategies used during FB across Europe. Methods and analysis The OxyFOB study is a large, prospective, international, observational cohort study which aims to involve over 10 000 FB procedures across European centres. Eligible participants include all adults undergoing FB for diagnostic, therapeutic or procedural indications. Data are collected via a standardised electronic case report form and encompass demographic information, procedural details and clinical outcomes. The primary endpoint is the prevalence of oxygenation and ventilatory support strategies: conventional oxygen therapy, high-flow oxygen therapy, continuous positive airway pressure, non-invasive ventilation and invasive mechanical ventilation. Secondary outcomes include periprocedural respiratory and haemodynamic events, patient comfort, dyspnoea and postprocedural complications. Statistical analyses include descriptive statistics, subgroup comparisons and multivariate logistic regression.
Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol / # 1, Federico Longhini; # 2, Claudia Crimi; 3, Alberto Noto; 4, Corrado Pelaia; 5, Zuhal Karakurt; 6, Szymon Skoczyński; 7, José Pedro Boléo-Tomé; 8, João Carlos Winck; M Esquinas 9, Antonio; Melhorn 10, James; Corneci 11, Dan; Pobeha 12, Pavol; 4, Vincenzo Bosco; 4, Eugenio Garofalo; 4, Andrea Bruni; Cammarota 13, Gianmaria; Todorova 14, Violeta; Valentina Puci 15, Mariangela; Sotgiu 15, Giovanni; Kostikas 16, Konstantinos; Maurizio Maggiore 17, Salvatore; De Robertis 18, Edoardo; Ergan 19, Begum; Landoni 20, Giovanni; Simonte 18, Rachele; Nava 21, Stefano; Navalesi 22, Paolo; Scala Zuhal Karakurt, Raffaele; Gundogus, Baran; Erdal Donmez, Gul; Ernam, Dilek; Campainha, Sergio; Oliveira, Ana; José Teixeira, Maria; Correia Gouveia, Francisco; Torres Monteiro, Catarina; Şimşek Veske, Nurdan; Altın, Sedat; Günlüoğlu, Gülşah; Gonca Chousein, Efsun; Arıkan, Hüseyin; Karakurt, Sait; Lacedonia, Donato; Torraco, Ruggiero; Tondo, Pasquale; Bialka, Szymon; Palaczynski, Piotr; Danel, Justyna; Jankowiak, Piotr; Kędra, Magdalena; Bednarska, Magdalena; Carpagnano, Elisiana; Boniello, Esterina; Portacci, Andrea; Scarlata, Simone; Finamore, Panaiotis; Fontata, Davide; Kania, Aleksander; Celejewska-Wojcik, Natalia; Rygiel, Klaudia; Tobiczyk, Ewelina; Springer, Daria; Cofta, Szczepan; Maugeri, Jessica; Bellissima, Agrippino; Tamburrini, Mario; Papi, Alberto; Morandi, Luca; Franco, Cosimo; Chiesa, Sara; Verti, Nicolò; Zieliński, Michał; Mondoni, Michele; Intravaia, Carmelo; Carlucci, Paolo; Karnak, Demet; Çiledağ, Aydın; Gürün Kaya, Aslıhan; Ghinassi, Giacomo; Guidelli, Luca; Santus, Pierachille; Radovanovic, Dejan; Saad, Marina; Figueiredo Roquete, Catarina; Petinga Fortes, Ricardo; Porpodis, Konstantinos; Tsiouprou, Ioanna; Lagoudi, Kalliopi; Pelaia, Girolamo; Marrazzo, Giuseppina; Montenegro, Nicola; Biondini, Davide; Damin, Marco; Spagnolo, Paolo; Oliveira Rodrigues, João; Oliveira Pinto, Mário; Castro Maia, Dionísio; Sampsonas, Fotios; Tzouvelekis, Argyrios; Tsirikos, Georgios; Loukides, Stelios; Raptakis, Thomas; Papavasileiou, Vasileios; Vaschetto, Rosanna; Tonino, Alessandro; Patrucco, Filippo; Estevão Gomes, Ricardo; Soares, Jorge; João Santana, Maria; Neri, Giuseppe; Corea, Angela; Caroleo, Antonio; Grande, Antonio; Veltri, Deborah; Costumato, Giulia; Di Lorenzo, Federica; Bonadio, Giuseppe; Caroleo, Zaninni; Guerriero, Giuseppe; Mazza, Giuseppe; Mellace, Federica; Perrelli, Giulia; Riillo, Silvia; Ruocco, Giuseppina; Camastra, Antonio; Gaetano, Giuseppe; Mesiti, Aldo; Guzzi, Giusy; Mastrangelo, Helenia; Pisani, Lara; Laura Vegapittao, Maria; Stratakos, Grigorios; Koukaki, Evangelia; Anagnostopoulos, Nektarios; Dongilli, Roberto; Stirpe, Emanuele; Köhl, Johanna; Skyba, Peter; Sokolová, Eva; Alvarenga Santos, Maria; Aguiar, Margarida; Zias, Nikos; Papadakis, Ioannis; Terragni, Pierpaolo; Pistidda, Laura; Castagna, Roberto; Popescu, Mihai; Rogliani, Paola; Puxeddu, Emanno; Frugoni, Chiara; Notaro, Salvatore; Piscitelli, Eugenio; Carrasco González, Elena; Higón Cañigral, Áurea; Turi, Stefano; Mucchetti, Marta; Belletti, Alessandro; Volonterio, Giorgia; Sommaruga, Sabina; Navarria, Roberta; Alessia Nardo, Andrea; Morana, Giorgio; Palmiotto, Giulia; Gabriele Iuliano, Antonio; Novais Bastos, Hélder; Scolletta, Sabino; Biuzzi, Cesare; Sorino, Claudio; Hida, Denisa; Arrighi, Eugenio; Gambardella, Paolo; Perri, Graziella; Cortegiani, Andrea; Ippolito, Mariachiara; Alessandri, Francesco; Cristian Sanda, Vlad; Zullino, Veronica; Rocco, Monica; Fiorelli, Silvia; Rolo Nunes, Lisete; Gregoretti, Cesare; Misseri, Giovanni; Piattoli, Matteo; Curto, Isacco; Tescione, Marco; Vadalà, Eugenio; Piccolo, Annalisa; Mammone, Selma; Gnass, Maciej; Gniady, Piotr; Steiropoulos, Paschalis; Drakopanagiotakis, Fotios; Gianozzi, Lucrezia; Chronis, Christos; Novelli, Luca; Katsoulis, Kostas; Fois, Alessandro Giuseppe; Oraczewska, Aleksandra. - In: BMJ OPEN. - ISSN 2044-6055. - (2025). [10.1136/bmjopen-2025-104747]
Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol
Giovanni Sotgiu 15;Ana Oliveira;Pierpaolo TerragniMembro del Collaboration Group
;Laura PistiddaMembro del Collaboration Group
;Roberto CastagnaMembro del Collaboration Group
;Alessandro Giuseppe FoisMembro del Collaboration Group
;
2025-01-01
Abstract
Introduction Flexible bronchoscopy (FB) is widely used for diagnostic and therapeutic procedures in pulmonary medicine. However, FB can cause respiratory and haemodynamic complications, especially in patients with pre-existing lung and/or cardiovascular comorbidities. Despite the range of oxygenation and ventilatory approaches available to prevent these risks, evidence regarding their real-world application and clinical impact is limited. The OxyFOB study aims to assess the prevalence and outcomes of various oxygenation and ventilatory support strategies used during FB across Europe. Methods and analysis The OxyFOB study is a large, prospective, international, observational cohort study which aims to involve over 10 000 FB procedures across European centres. Eligible participants include all adults undergoing FB for diagnostic, therapeutic or procedural indications. Data are collected via a standardised electronic case report form and encompass demographic information, procedural details and clinical outcomes. The primary endpoint is the prevalence of oxygenation and ventilatory support strategies: conventional oxygen therapy, high-flow oxygen therapy, continuous positive airway pressure, non-invasive ventilation and invasive mechanical ventilation. Secondary outcomes include periprocedural respiratory and haemodynamic events, patient comfort, dyspnoea and postprocedural complications. Statistical analyses include descriptive statistics, subgroup comparisons and multivariate logistic regression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
