Aims: High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes. Methods: Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population. Results: Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd. Conclusion: G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.

Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes / Scuteri, A.; Morrell, C. H.; Alghatrif, M.; Orru, M.; Fiorillo, E.; Marongiu, M.; Schlessinger, D.; Cucca, F.; Lakatta, E. G.. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - 61:1(2024), pp. 127-130. [10.1007/s00592-023-02118-8]

Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes

Scuteri A.;Cucca F.;
2024-01-01

Abstract

Aims: High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes. Methods: Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population. Results: Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd. Conclusion: G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.
2024
Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes / Scuteri, A.; Morrell, C. H.; Alghatrif, M.; Orru, M.; Fiorillo, E.; Marongiu, M.; Schlessinger, D.; Cucca, F.; Lakatta, E. G.. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - 61:1(2024), pp. 127-130. [10.1007/s00592-023-02118-8]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/346569
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact