Background: Among the Pentraxins, the long Pentraxin-3 (PTX-3) is associated with several processes, particularly in the earliest phases of the innate humoral response. Increased blood PTX-3 concentrations have been observed in a wide range of conditions, from infectious to cardiovascular disorders. Since its increase is more rapid than C-reactive protein (CRP), PTX-3 can be useful to detect and monitor early inflammation. To dissect its pathophysiological role in rheumatic diseases (RD), we conducted a systematic review and meta-analysis comparing blood PTX-3 concentrations in RD patients and healthy individuals and investigating possible associations with clinical, demographic, and study characteristics. Methods: We performed a search of published evidence until April 2024 in PubMed, Web of Science and Scopus, which led to the selection of 60 relevant manuscripts from a total of 1072 records. Results: Our synthesis revealed a statistically significant difference in PTX-3 concentrations between RD patients and controls (standard mean difference, SMD = 1.02, 95% CI 0.77-1.26, p < .001), that correlated with CRP concentrations. The effect size was associated with geographical region of study conduction, RD type, with a reduction of the observed heterogeneity in patients with low LDL-cholesterol and triglycerides concentrations. Conclusions: Our study has shown a significant increase in blood PTX-3 concentrations in RD patients, which was associated with specific patient characteristics. Nevertheless, additional studies are needed to better define the utility of measuring PTX-3 in the early phase of RD. Our study was conducted in compliance with the PRISMA 2020 statement (study protocol available at PROSPERO CRD42024516600).

Association between blood Pentraxin-3 concentrations and rheumatic diseases: A systematic review and meta-analysis / Di Lorenzo, Biagio; Zoroddu, Stefano; Mangoni, Arduino A; Sotgia, Salvatore; Paliogiannis, Panagiotis; Erre, Gian Luca; Carru, Ciriaco; Zinellu, Angelo. - In: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - ISSN 1365-2362. - (2024). [10.1111/eci.14257]

Association between blood Pentraxin-3 concentrations and rheumatic diseases: A systematic review and meta-analysis

Di Lorenzo, Biagio;Zoroddu, Stefano;Sotgia, Salvatore;Paliogiannis, Panagiotis;Erre, Gian Luca;Carru, Ciriaco;Zinellu, Angelo
2024-01-01

Abstract

Background: Among the Pentraxins, the long Pentraxin-3 (PTX-3) is associated with several processes, particularly in the earliest phases of the innate humoral response. Increased blood PTX-3 concentrations have been observed in a wide range of conditions, from infectious to cardiovascular disorders. Since its increase is more rapid than C-reactive protein (CRP), PTX-3 can be useful to detect and monitor early inflammation. To dissect its pathophysiological role in rheumatic diseases (RD), we conducted a systematic review and meta-analysis comparing blood PTX-3 concentrations in RD patients and healthy individuals and investigating possible associations with clinical, demographic, and study characteristics. Methods: We performed a search of published evidence until April 2024 in PubMed, Web of Science and Scopus, which led to the selection of 60 relevant manuscripts from a total of 1072 records. Results: Our synthesis revealed a statistically significant difference in PTX-3 concentrations between RD patients and controls (standard mean difference, SMD = 1.02, 95% CI 0.77-1.26, p < .001), that correlated with CRP concentrations. The effect size was associated with geographical region of study conduction, RD type, with a reduction of the observed heterogeneity in patients with low LDL-cholesterol and triglycerides concentrations. Conclusions: Our study has shown a significant increase in blood PTX-3 concentrations in RD patients, which was associated with specific patient characteristics. Nevertheless, additional studies are needed to better define the utility of measuring PTX-3 in the early phase of RD. Our study was conducted in compliance with the PRISMA 2020 statement (study protocol available at PROSPERO CRD42024516600).
2024
Association between blood Pentraxin-3 concentrations and rheumatic diseases: A systematic review and meta-analysis / Di Lorenzo, Biagio; Zoroddu, Stefano; Mangoni, Arduino A; Sotgia, Salvatore; Paliogiannis, Panagiotis; Erre, Gian Luca; Carru, Ciriaco; Zinellu, Angelo. - In: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - ISSN 1365-2362. - (2024). [10.1111/eci.14257]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/336330
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