A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort

Kondili, L. A.; Brancaccio, G.; Tosti, M. E.; Coco, B.; Quaranta, M. G.; Messina, V.; Ciancio, A.; Morisco, F.; Cossiga, V.; Claar, E.; Rosato, V.; Ciarallo, M.; Cacciola, I.; Ponziani, F. R.; Cerrito, L.; Coppola, R.; Longobardi, F.; Biliotti, E.; Rianda, A.; Barbaro, F.; Coppola, N.; Stanzione, M.; Barchiesi, F.; Fagiuoli, S.; Vigano, M.; Massari, M.; Russo, F. P.; Ferrarese, A.; Laccabue, D.; Di Marco, V.; Blanc, P.; Marrone, A.; Morsica, G.; Federico, A.; Ieluzzi, D.; Rocco, A.; Foschi, F. G.; Soria, A.; Maida, I.; Chessa, L.; Milella, M.; Rosselli Del Turco, E.; Madonia, S.; Chemello, L.; Gentile, I.; Toniutto, P.; Bassetti, M.; Surace, L.; Baiocchi, L.; Pellicelli, A.; De Santis, A.; Puoti, M.; Degasperi, E.; Niro, G. A.; Zignego, A. L.; Craxi, A.; Raimondo, G.; Santantonio, T. A.; Brunetto, M. R.; Gaeta, G. B.; Aghemo, A.; Baiguera, C.; Battezzati, P. M.; Battistella, S.; Bavetta, M. G.; Bertoni, C.; Boni, C.; Brambilla, P.; Bray, A.; Briano, F.; Carmenini, E.; Castelli, F.; Cavalletto, L.; Cerini, F.; Chidichimo, L.; Colella, E.; Cologni, G.; Como, S.; Corsini, R.; Costa, C.; Cotugno, R.; Cretella, S.; De Angelis, F.; De Leo, P.; Perri, G. D.; Falbo, E.; Ferrigno, L.; Fornasiere, E.; Francisci, D.; Gatti, P.; Lampertico, P.; Lenci, I.; Licata, A.; Marzano, A.; Mastroianni, A.; Mazzaro, C.; Monti, M.; Nardone, G.; Nicolini, L. A.; Passigato, N.; Pasticci, M. B.; Pierotti, P.; Pinchera, B.; Pollicino, T.; Porcu, C.; Quartini, G.; Rancatore, G.; Romeo, M.; Rumi, M. G.; Saracino, A.; Schioppa, O.; Serio, I.; Soffredini, R.; Tata, X.; Tizzani, M.; Tonnini, M.; Torti, C.; Valenti, D.; Zaltron, S.; Zoncada, A.

doi:10.1016/j.ijid.2024.107115

Background and aims: We aimed to characterize the epidemiologic and comorbidities profiles of patients with chronic Hepatitis D (CHD) followed in clinical practice in Italy and explored their interferon (IFN) eligibility. Methods: This was a cross-sectional study of the PITER cohort consisting of consecutive HBsAg-positive patients from 59 centers over the period 2019-2023. Multivariable analysis was performed by logistic regression model. Results: Of 5492 HBsAg-positive enrolled patients, 4152 (75.6%) were screened for HDV, 422 (10.2%) were anti-HDV positive. Compared with HBsAg mono-infected, anti-HDV positive patients were more often younger, non-Italians, with a history of drug use, had elevated alanine transaminase (ALT), cirrhosis, or hepatocellular carcinoma (HCC). Compared with Italians, anti-HDV positive non-Italians were younger (42.2% age ≤ 40 years vs. 2.1%; P < 0.001), more often females (males 43.0% vs. 68.6%; P < 0.001) with less frequent cirrhosis and HCC. HDV-RNA was detected in 63.2% of anti-HDV-positive patients, who were more likely to have elevated ALT, cirrhosis, and HCC. Extrahepatic comorbidities were present in 47.4% of anti-HDV positive patients and could affect the eligibility of IFN-containing therapies in at least 53.0% of patients in care. Conclusions: CHD affects young, foreign-born patients and older Italians, of whom two-thirds had cirrhosis or HCC. Comorbidities were frequent in both Italians and non-Italians and impacted eligibility for IFN.

A holistic evaluation of patients with chronic Hepatitis D virus (HDV) infection enrolled in the Italian PITER-B and delta cohort / Kondili, L. A.; Brancaccio, G.; Tosti, M. E.; Coco, B.; Quaranta, M. G.; Messina, V.; Ciancio, A.; Morisco, F.; Cossiga, V.; Claar, E.; Rosato, V.; Ciarallo, M.; Cacciola, I.; Ponziani, F. R.; Cerrito, L.; Coppola, R.; Longobardi, F.; Biliotti, E.; Rianda, A.; Barbaro, F.; Coppola, N.; Stanzione, M.; Barchiesi, F.; Fagiuoli, S.; Vigano, M.; Massari, M.; Russo, F. P.; Ferrarese, A.; Laccabue, D.; Di Marco, V.; Blanc, P.; Marrone, A.; Morsica, G.; Federico, A.; Ieluzzi, D.; Rocco, A.; Foschi, F. G.; Soria, A.; Maida, I.; Chessa, L.; Milella, M.; Rosselli Del Turco, E.; Madonia, S.; Chemello, L.; Gentile, I.; Toniutto, P.; Bassetti, M.; Surace, L.; Baiocchi, L.; Pellicelli, A.; De Santis, A.; Puoti, M.; Degasperi, E.; Niro, G. A.; Zignego, A. L.; Craxi, A.; Raimondo, G.; Santantonio, T. A.; Brunetto, M. R.; Gaeta, G. B.; Aghemo, A.; Baiguera, C.; Battezzati, P. M.; Battistella, S.; Bavetta, M. G.; Bertoni, C.; Boni, C.; Brambilla, P.; Bray, A.; Briano, F.; Carmenini, E.; Castelli, F.; Cavalletto, L.; Cerini, F.; Chidichimo, L.; Colella, E.; Cologni, G.; Como, S.; Corsini, R.; Costa, C.; Cotugno, R.; Cretella, S.; De Angelis, F.; De Leo, P.; Perri, G. D.; Falbo, E.; Ferrigno, L.; Fornasiere, E.; Francisci, D.; Gatti, P.; Lampertico, P.; Lenci, I.; Licata, A.; Marzano, A.; Mastroianni, A.; Mazzaro, C.; Monti, M.; Nardone, G.; Nicolini, L. A.; Passigato, N.; Pasticci, M. B.; Pierotti, P.; Pinchera, B.; Pollicino, T.; Porcu, C.; Quartini, G.; Rancatore, G.; Romeo, M.; Rumi, M. G.; Saracino, A.; Schioppa, O.; Serio, I.; Soffredini, R.; Tata, X.; Tizzani, M.; Tonnini, M.; Torti, C.; Valenti, D.; Zaltron, S.; Zoncada, A.. - In: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. - ISSN 1201-9712. - 146:(2024). [10.1016/j.ijid.2024.107115]