BackgroundSTN1013001 is an innovative latanoprost cationic emulsion for open-angle glaucoma/ocular hypertension (OAG/OHT) and ocular surface disease (OSD).Methods and findingsA 5-year, 7 health states, 1-year cycle early Markov model-supported cost-utility analysis (CUA) of STN1013001 vs. other latanoprost formulations (Latanoprost) followed the Italian National Health Service (INHS) perspective.One-way, probabilistic and scenario sensitivity analyses tested the uncertainty of the baseline results. Value of information analysis (VOIA) investigated the potential cost-effectiveness of collecting further evidence.ResultsOver 5 years, the Markov model-supported CUA predicts STN1013001 to be potentially highly cost-effective vs. Latanoprost (+euro57.60 cost at euro2020 values; +0.089 Quality-Adjusted Life Years).The Incremental Cost-Utility Ratio (euro647.65) falls well below the lower limit of the acceptability range proposed for Italy (euro25,000-euro40,000).Sensitivity analyses confirmed the robustness of the baseline findings. VOIA highlighted that further information might only be cost-effective for OAG/OHT utilities and OSD-related disutility.ConclusionSTN1013001 is potentially highly cost-effective and strongly dominant vs. Latanoprost for OAG/OHT+OSD patients from the INHS perspective. These findings should be re-assessed using the data from the ongoing Phase III trial (NCT04133311) comparing the efficacy and safety of STN1013001 vs. Latanoprost and with future real-world CUAs upon the availability of STN1013001 on the Italian market.

A latanoprost cationic emulsion (STN1013001) vs. other latanoprost formulations (Latanoprost) in open angle glaucoma/ocular hypertension and ocular surface disease: an Italian cost-utility analysis / Lazzaro, Carlo; van Steen, Cécile; Ghirelli, Giorgio; Sacchi, Matteo; Sisto, Dario; Uva, Maurizio; Varano, Luigi; Angelillo, Luigi. - In: EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH. - ISSN 1473-7167. - 23:2(2023). [10.1080/14737167.2023.2161515]

A latanoprost cationic emulsion (STN1013001) vs. other latanoprost formulations (Latanoprost) in open angle glaucoma/ocular hypertension and ocular surface disease: an Italian cost-utility analysis

Sacchi, Matteo;
2023-01-01

Abstract

BackgroundSTN1013001 is an innovative latanoprost cationic emulsion for open-angle glaucoma/ocular hypertension (OAG/OHT) and ocular surface disease (OSD).Methods and findingsA 5-year, 7 health states, 1-year cycle early Markov model-supported cost-utility analysis (CUA) of STN1013001 vs. other latanoprost formulations (Latanoprost) followed the Italian National Health Service (INHS) perspective.One-way, probabilistic and scenario sensitivity analyses tested the uncertainty of the baseline results. Value of information analysis (VOIA) investigated the potential cost-effectiveness of collecting further evidence.ResultsOver 5 years, the Markov model-supported CUA predicts STN1013001 to be potentially highly cost-effective vs. Latanoprost (+euro57.60 cost at euro2020 values; +0.089 Quality-Adjusted Life Years).The Incremental Cost-Utility Ratio (euro647.65) falls well below the lower limit of the acceptability range proposed for Italy (euro25,000-euro40,000).Sensitivity analyses confirmed the robustness of the baseline findings. VOIA highlighted that further information might only be cost-effective for OAG/OHT utilities and OSD-related disutility.ConclusionSTN1013001 is potentially highly cost-effective and strongly dominant vs. Latanoprost for OAG/OHT+OSD patients from the INHS perspective. These findings should be re-assessed using the data from the ongoing Phase III trial (NCT04133311) comparing the efficacy and safety of STN1013001 vs. Latanoprost and with future real-world CUAs upon the availability of STN1013001 on the Italian market.
2023
A latanoprost cationic emulsion (STN1013001) vs. other latanoprost formulations (Latanoprost) in open angle glaucoma/ocular hypertension and ocular surface disease: an Italian cost-utility analysis / Lazzaro, Carlo; van Steen, Cécile; Ghirelli, Giorgio; Sacchi, Matteo; Sisto, Dario; Uva, Maurizio; Varano, Luigi; Angelillo, Luigi. - In: EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH. - ISSN 1473-7167. - 23:2(2023). [10.1080/14737167.2023.2161515]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/326852
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact