Our research has demonstrated that mechanochemical activation is more effective with solid reagents. We have showcased the practicality of Bertagnini's salts, also called aldehyde-bisulfite adducts, which are crystalline, simplifying preparation and storage. These salts are stable substitutes for liquid aldehydes and ketones that have been employed in reductive amination, synthesizing aza-heterocycles and hydrazones within mechanochemistry. The technique‘s effectiveness broadens the substrate scopes, simplifies purification, reduces reaction times, and yields the desired products ranging from 38–91%. Additionally, the thermal stability of the bisulfite adducts has been confirmed through TGA (Thermogravimetric analysis) analysis.

Application of Bertagnini's Salts in a Mechanochemical Approach Toward Aza-Heterocycles and Reductive Aminations via Imine Formation / Behera, S.; Kanti Bera, S.; Basoccu, F.; Cuccu, F.; Caboni, P.; De Luca, L.; Porcheddu, A.. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4150. - (2024). [10.1002/adsc.202301407]

Application of Bertagnini's Salts in a Mechanochemical Approach Toward Aza-Heterocycles and Reductive Aminations via Imine Formation

De Luca L.;
2024-01-01

Abstract

Our research has demonstrated that mechanochemical activation is more effective with solid reagents. We have showcased the practicality of Bertagnini's salts, also called aldehyde-bisulfite adducts, which are crystalline, simplifying preparation and storage. These salts are stable substitutes for liquid aldehydes and ketones that have been employed in reductive amination, synthesizing aza-heterocycles and hydrazones within mechanochemistry. The technique‘s effectiveness broadens the substrate scopes, simplifies purification, reduces reaction times, and yields the desired products ranging from 38–91%. Additionally, the thermal stability of the bisulfite adducts has been confirmed through TGA (Thermogravimetric analysis) analysis.
2024
Application of Bertagnini's Salts in a Mechanochemical Approach Toward Aza-Heterocycles and Reductive Aminations via Imine Formation / Behera, S.; Kanti Bera, S.; Basoccu, F.; Cuccu, F.; Caboni, P.; De Luca, L.; Porcheddu, A.. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4150. - (2024). [10.1002/adsc.202301407]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/326470
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