Context: It is unclear whether a magnetic resonance imaging (MRI)-targeted transperineal (TP) biopsy can improve the detection of clinically significant prostate cancer (csPCa). Objective: To compare the MRI-targeted TP and transrectal (TR) approaches for csPCa detection. Evidence acquisition: A literature search was conducted using the PubMed/Medline, Embase, and Web of Science databases to identify reports published until February 2023. The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed to identify eligible studies. The primary outcome was the detection of csPCa (Gleason grade group 0.001) and apical (OR 1.86, 95% CI 1.14-3.03; p = 0.01) lesions. In the subgroup analysis based on PI-RADS score, the TP approach was associated with higher csPCa detection (OR 1.57, 95% CI 1.07-2.29; p = 0.02) in PI-RADS 4 lesions. Conversely, no difference was found in PI-RADS 3 and 5 lesions (p 0.05). The main limitation was the retrospective design of most included studies. Conclusions: No significant association was found between the prostate biopsy approach and csPCa detection rate when we considered all biopsy indications. The TP approach provides a detection advantage in anterior and apical tumors, arguing for a preferred use of the TP approach in these lesion locations. Patient summary: The transperineal magnetic resonance imaging-targeted prostate biopsy approach appears to be more effective only for selected lesions. No clear benefit was seen for the transperineal approach in the overall population. (c) 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy in Clinically Significant Prostate Cancer Detection Rate? A Systematic Review and Meta-analysis / Uleri, Alessandro; Baboudjian, Michael; Tedde, Alessandro; Gallioli, Andrea; Long-Depaquit, Thibaut; Palou, Joan; Basile, Giuseppe; Gaya, Josep Maria; Sanguedolce, Francesco; Lughezzani, Giovanni; Rajwa, Pawel; Pradere, Benjamin; Roupret, Morgan; Briganti, Alberto; Ploussard, Guillaume; Breda, Alberto. - In: EUROPEAN UROLOGY ONCOLOGY. - ISSN 2588-9311. - 6:6(2023), pp. 621-628. [10.1016/j.euo.2023.08.001]

Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy in Clinically Significant Prostate Cancer Detection Rate? A Systematic Review and Meta-analysis

Tedde, Alessandro;Sanguedolce, Francesco;
2023-01-01

Abstract

Context: It is unclear whether a magnetic resonance imaging (MRI)-targeted transperineal (TP) biopsy can improve the detection of clinically significant prostate cancer (csPCa). Objective: To compare the MRI-targeted TP and transrectal (TR) approaches for csPCa detection. Evidence acquisition: A literature search was conducted using the PubMed/Medline, Embase, and Web of Science databases to identify reports published until February 2023. The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed to identify eligible studies. The primary outcome was the detection of csPCa (Gleason grade group 0.001) and apical (OR 1.86, 95% CI 1.14-3.03; p = 0.01) lesions. In the subgroup analysis based on PI-RADS score, the TP approach was associated with higher csPCa detection (OR 1.57, 95% CI 1.07-2.29; p = 0.02) in PI-RADS 4 lesions. Conversely, no difference was found in PI-RADS 3 and 5 lesions (p 0.05). The main limitation was the retrospective design of most included studies. Conclusions: No significant association was found between the prostate biopsy approach and csPCa detection rate when we considered all biopsy indications. The TP approach provides a detection advantage in anterior and apical tumors, arguing for a preferred use of the TP approach in these lesion locations. Patient summary: The transperineal magnetic resonance imaging-targeted prostate biopsy approach appears to be more effective only for selected lesions. No clear benefit was seen for the transperineal approach in the overall population. (c) 2023 European Association of Urology. Published by Elsevier B.V. All rights reserved.
2023
Is There an Impact of Transperineal Versus Transrectal Magnetic Resonance Imaging-targeted Biopsy in Clinically Significant Prostate Cancer Detection Rate? A Systematic Review and Meta-analysis / Uleri, Alessandro; Baboudjian, Michael; Tedde, Alessandro; Gallioli, Andrea; Long-Depaquit, Thibaut; Palou, Joan; Basile, Giuseppe; Gaya, Josep Maria; Sanguedolce, Francesco; Lughezzani, Giovanni; Rajwa, Pawel; Pradere, Benjamin; Roupret, Morgan; Briganti, Alberto; Ploussard, Guillaume; Breda, Alberto. - In: EUROPEAN UROLOGY ONCOLOGY. - ISSN 2588-9311. - 6:6(2023), pp. 621-628. [10.1016/j.euo.2023.08.001]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/324970
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