Background: Cutaneous adverse events (CAEs) related to oncological therapies are a common scenario in daily clinical practice. Methods: This is a retrospective observational study collecting the data regarding CAEs of patients treated with immune checkpoints inhibitors (ICIs) in four different Italian centers. Results: Of 323 patients included, 305 were evaluable for this analysis; 182 patients (59.7%) had metastatic cutaneous melanoma (CM), 99 (32.5%) non-small cell lung cancer (NSCLC) and 24 (7.8%) renal cell carcinoma (RCC). The most frequent CAEs that we found, considering all the 305 patients, were pruriginous maculopapular rash (10.2% of the patients), vitiligo-like areas (7.2% of the patients), psoriasiform rash (6.2% of the patients), asymptomatic maculopapular rash (4.6% of the patients), and lichenoid rash (4.3% of the patients). Vitiligo-like areas occurred more frequently in patients with CM, while a lichenoid rash was more frequently observed in patients with RCC. Treatment interruption was related to drug-induced CAEs in 15.4% of melanoma patients and 0.0% of lung and kidney patients. Patients developing a cutaneous adverse event had better overall response rate and higher progression free survival and overall survival than the patients without CAEs. Conclusions: Our study brings new information on the characteristics of CAEs related to ICIs treatment in three different types of cancers, CM, NSCLC and RCC.

A retrospective observational study on cutaneous adverse events induced by immune checkpoint inhibitors / Medri, Matelda; Savoia, Francesco; Foca, Flavia; Miserocchi, Anna; Quaglino, Pietro; Rubatto, Marco; Gullo, Giulia; Nardini, Chiara; Panasiti, Vincenzo; DE Tursi, Michele; DI Marino, Pietro; Brancaccio, Gabriella; Giunta, Emilio F; Napolitano, Stefania; Cinotti, Elisa; Brusasco, Marco; Stanganelli, Ignazio; Massi, Daniela; Quaglino, Pietro; Caracò, Corrado; Ferraresi, Virginia; Grimaldi, Antonio M; Patuzzo, Roberto; Palmieri, Giuseppe; Mandalà, Mario. - In: ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY. - ISSN 2784-8671. - 158:6(2023), pp. 437-444. [10.23736/S2784-8671.23.07542-4]

A retrospective observational study on cutaneous adverse events induced by immune checkpoint inhibitors

Palmieri, Giuseppe;
2023-01-01

Abstract

Background: Cutaneous adverse events (CAEs) related to oncological therapies are a common scenario in daily clinical practice. Methods: This is a retrospective observational study collecting the data regarding CAEs of patients treated with immune checkpoints inhibitors (ICIs) in four different Italian centers. Results: Of 323 patients included, 305 were evaluable for this analysis; 182 patients (59.7%) had metastatic cutaneous melanoma (CM), 99 (32.5%) non-small cell lung cancer (NSCLC) and 24 (7.8%) renal cell carcinoma (RCC). The most frequent CAEs that we found, considering all the 305 patients, were pruriginous maculopapular rash (10.2% of the patients), vitiligo-like areas (7.2% of the patients), psoriasiform rash (6.2% of the patients), asymptomatic maculopapular rash (4.6% of the patients), and lichenoid rash (4.3% of the patients). Vitiligo-like areas occurred more frequently in patients with CM, while a lichenoid rash was more frequently observed in patients with RCC. Treatment interruption was related to drug-induced CAEs in 15.4% of melanoma patients and 0.0% of lung and kidney patients. Patients developing a cutaneous adverse event had better overall response rate and higher progression free survival and overall survival than the patients without CAEs. Conclusions: Our study brings new information on the characteristics of CAEs related to ICIs treatment in three different types of cancers, CM, NSCLC and RCC.
2023
A retrospective observational study on cutaneous adverse events induced by immune checkpoint inhibitors / Medri, Matelda; Savoia, Francesco; Foca, Flavia; Miserocchi, Anna; Quaglino, Pietro; Rubatto, Marco; Gullo, Giulia; Nardini, Chiara; Panasiti, Vincenzo; DE Tursi, Michele; DI Marino, Pietro; Brancaccio, Gabriella; Giunta, Emilio F; Napolitano, Stefania; Cinotti, Elisa; Brusasco, Marco; Stanganelli, Ignazio; Massi, Daniela; Quaglino, Pietro; Caracò, Corrado; Ferraresi, Virginia; Grimaldi, Antonio M; Patuzzo, Roberto; Palmieri, Giuseppe; Mandalà, Mario. - In: ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY. - ISSN 2784-8671. - 158:6(2023), pp. 437-444. [10.23736/S2784-8671.23.07542-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/320930
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