AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv ≥ 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate ≥ 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2)•(IGFBP7) ≥ 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.

Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit / Ferrari, F.; Puci, M. V.; Ferraro, O. E.; Romero-Gonzalez, G.; Husain-Syed, F.; Rizo-Topete, L.; Senzolo, M.; Lorenzin, A.; Muraro, E.; Baracca, A.; Serrano-Soto, M.; Trivino, A. M.; Castro, A. C.; De Cal, M.; Corradi, V.; Brendolan, A.; Scarpa, M.; Carta, M. R.; Giavarina, D.; Bonato, R.; Iotti, G. A.; Ronco, C.. - In: PLOS ONE. - ISSN 1932-6203. - 14:6(2019), p. e0217424. [10.1371/journal.pone.0217424]

Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit

Puci M. V.;
2019-01-01

Abstract

AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv ≥ 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate ≥ 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2)•(IGFBP7) ≥ 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.
2019
Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit / Ferrari, F.; Puci, M. V.; Ferraro, O. E.; Romero-Gonzalez, G.; Husain-Syed, F.; Rizo-Topete, L.; Senzolo, M.; Lorenzin, A.; Muraro, E.; Baracca, A.; Serrano-Soto, M.; Trivino, A. M.; Castro, A. C.; De Cal, M.; Corradi, V.; Brendolan, A.; Scarpa, M.; Carta, M. R.; Giavarina, D.; Bonato, R.; Iotti, G. A.; Ronco, C.. - In: PLOS ONE. - ISSN 1932-6203. - 14:6(2019), p. e0217424. [10.1371/journal.pone.0217424]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/319544
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