The aim of this study is to demonstrate the antifungal, anti-inflammatory and anti-migratory potential of the essential oil of Teucrium scordium subsp. scordioides (Schreb.) Arcang, a plant widely used in traditional medicine in Sardinia. The oil was rich in germacrene D (25.1%), d-cadinene (12.9%) and alloaromadendrene (11.3%). The yeast Cryptococcus neoformans and the dermatophytes Trichophyton rubrum, T. mentagrophytes var. interdigitale and Epidermophyton floccosum were the most susceptible fungi to the action of the oil. In lipopolysaccharide (LPS)-stimulated macrophages, the oil was able to decrease nitric oxide production by ca. 30% at 1.25 lL/mL, without affecting cell viability. In the scratch wound assay, it allowed for ca. 36% of wound closure after 18 h, thus showing anti-migratory properties. Overall, this study highlights the potential of this species to mitigate fungal infections associated with an inflammatory response. Furthermore, we also reported for the first time its antimigratory capacity, thus suggesting anticancer properties.

Chemical composition and biological activity of essential oil of Teucrium scordium L. subsp. scordioides (Schreb.) Arcang. (Lamiaceae) from Sardinia Island (Italy) / Piras, Alessandra; Maccioni, Alfredo; Falconieri, Danilo; Porcedda, Silvia; José Gonçalves, Maria; Alves-Silva, Jorge M.; Silva, Ana; Teresa Cruz, Maria; Salgueiro, Ligia; Maxia, Andrea. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - (2022).

Chemical composition and biological activity of essential oil of Teucrium scordium L. subsp. scordioides (Schreb.) Arcang. (Lamiaceae) from Sardinia Island (Italy)

Alfredo Maccioni;Silvia Porcedda;
2022-01-01

Abstract

The aim of this study is to demonstrate the antifungal, anti-inflammatory and anti-migratory potential of the essential oil of Teucrium scordium subsp. scordioides (Schreb.) Arcang, a plant widely used in traditional medicine in Sardinia. The oil was rich in germacrene D (25.1%), d-cadinene (12.9%) and alloaromadendrene (11.3%). The yeast Cryptococcus neoformans and the dermatophytes Trichophyton rubrum, T. mentagrophytes var. interdigitale and Epidermophyton floccosum were the most susceptible fungi to the action of the oil. In lipopolysaccharide (LPS)-stimulated macrophages, the oil was able to decrease nitric oxide production by ca. 30% at 1.25 lL/mL, without affecting cell viability. In the scratch wound assay, it allowed for ca. 36% of wound closure after 18 h, thus showing anti-migratory properties. Overall, this study highlights the potential of this species to mitigate fungal infections associated with an inflammatory response. Furthermore, we also reported for the first time its antimigratory capacity, thus suggesting anticancer properties.
2022
Chemical composition and biological activity of essential oil of Teucrium scordium L. subsp. scordioides (Schreb.) Arcang. (Lamiaceae) from Sardinia Island (Italy) / Piras, Alessandra; Maccioni, Alfredo; Falconieri, Danilo; Porcedda, Silvia; José Gonçalves, Maria; Alves-Silva, Jorge M.; Silva, Ana; Teresa Cruz, Maria; Salgueiro, Ligia; Maxia, Andrea. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - (2022).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/314170
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