Background and purpose Some studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 mu g/m(3) (PM2.5), may contribute to severe COVID-19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID-19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID-19 severity amongst PwMS. Methods Data were retrieved from an Italian web-based platform (MuSC-19) which includes PwMS with COVID-19. PM2.5 2016-2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID-19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID-19 severity. Results In all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID-19 course (odds ratio 1.90; p = 0.009). Conclusions Even if several other factors explain the unfavourable course of COVID-19 in PwMS, the role of air pollutants must be considered and further investigated.
The effect of air pollution on COVID-19 severity in a sample of patients with multiple sclerosis / Bergamaschi, Roberto; Ponzano, Marta; Schiavetti, Irene; Carmisciano, Luca; Cordioli, Cinzia; Filippi, Massimo; Radaelli, Marta; Immovilli, Paolo; Capobianco, Marco; De Rossi, Nicola; Brichetto, Giampaolo; Cocco, Eleonora; Scandellari, Cinzia; Cavalla, Paola; Pesci, Ilaria; Zito, Antonio; Confalonieri, Paolo; Marfia, Girolama Alessandra; Perini, Paola; Inglese, Matilde; Trojano, Maria; Brescia Morra, Vincenzo; Pisoni, Enrico; Tedeschi, Gioacchino; Comi, Giancarlo; Battaglia, Mario Alberto; Patti, Francesco; Salvetti, Marco; Sormani, Maria Pia; Abbadessa, Gianmarco; Aguglia, Umberto; Allegorico, Lia; Allegri, Rossi Beatrice Maria; Alteno, Anastasia; Amato, Maria Pia; Annovazzi, Pietro; Antozzi, Carlo; Appendino, Lucia; Arena, Sebastiano; Baione, Viola; Balgera, Roberto; Barcella, Valeria; Baroncini, Damiano; Barrilà, Caterina; Battaglia, Mario A.; Bellacosa, Alessandra; Bellucci, Gianmarco; Bergamaschi, Valeria; Bezzini, Daiana; Biolzi, Beatrice; Bisecco, Alvino; Bonavita, Simona; Borriello, Giovanna; Bosa, Chiara; Bosco, Antonio; Bovis, Francesca; Bozzali, Marco; Brambilla, Laura; Brescia, Morra Vincenzo; Buccafusca, Maria; Bucciantini, Elisabetta; Bucello, Sebastiano; Buscarinu, Maria Chiara; Cabboi, Maria Paola; Calabrese, Massimiliano; Calabria, Francesca; Caleri, Francesca; Camilli, Federico; Caniatti, Luisa Maria; Cantello, Roberto; Capra, Ruggero; Capuano, Rocco; Carta, Patrizia; Celani, Maria Grazia; Cellerino, Maria; Cerqua, Raffaella; Chisari, Clara; Clerici, Raffaella; Clerico, Marinella; Cola, Gaia; Conte, Antonella; Conti, Marta Zaffira; Cordano, Christian; Cordera, Susanna; Corea, Francesco; Correale, Claudio; Cottone, Salvatore; Crescenzo, Francesco; Curti, Erica; D'Ambrosio, Alessandro; D'Amico, Emanuele; Danni, Maura Chiara; D'Arma, Alessia; Dattola, Vincenzo; de Biase, Stefano; De Luca, Giovanna; De Mercanti, Stefania Federica; De Mitri, Paolo; De Stefano, Nicola; Della, Cava Marco; di Napoli, Mario; Di Sapio, Alessia; Docimo, Renato; Dutto, Anna; Evangelista, Luana; Fanara, Salvatore; Ferraro, Diana; Ferrò, Maria Teresa; Fioretti, Cristina; Fratta, Mario; Frau, Jessica; Fronza, Marzia; Furlan, Roberto; Gajofatto, Alberto; Gallo, Antonio; Gallo, Paolo; Gasperini, Claudio; Ghazaryan, Anna; Giometto, Bruno; Gobbin, Francesca; Zarbo, Ignazio Roberto. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 29:2(2022), pp. 535-542. [10.1111/ene.15167]
The effect of air pollution on COVID-19 severity in a sample of patients with multiple sclerosis
Bosa, Chiara;Cabboi, Maria Paola;Carta, Patrizia;Zarbo, Ignazio RobertoMembro del Collaboration Group
2022-01-01
Abstract
Background and purpose Some studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 mu g/m(3) (PM2.5), may contribute to severe COVID-19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID-19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID-19 severity amongst PwMS. Methods Data were retrieved from an Italian web-based platform (MuSC-19) which includes PwMS with COVID-19. PM2.5 2016-2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID-19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID-19 severity. Results In all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID-19 course (odds ratio 1.90; p = 0.009). Conclusions Even if several other factors explain the unfavourable course of COVID-19 in PwMS, the role of air pollutants must be considered and further investigated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
