Introduction: Coronavirus Disease-19 (COVID-19) vaccines reduce the risk of severe disease and mortality. However, the association between vaccination status and number of doses and the PaO2/FiO(2) ratio, a clinical measure of hypoxemia associated with an increased risk of intensive care treatment and mortality, has not been investigated. Methods: We retrospectively assessed a consecutive series of 116 patients admitted to hospital with a primary diagnosis of COVID-19 between January and April 2022. Demographic, clinical, and laboratory data were collected within 24 h from admission. Results: There was a significant positive relationship between the number of vaccine doses and the PaO2/FiO(2) ratio (r = 0.223, p = 0.012). This association remained significant after adjusting for confounders. Vaccinated patients had significantly higher PaO2/FiO(2) ratios than the unvaccinated (median: 250; IQR: 195-309 vs. 200; IQR: 156-257, p = 0.013). Conclusion: These results highlight the importance of the number of vaccine doses received in reducing the degree of hypoxia on admission in hospitalized COVID-19 patients.

Vaccination Status and Number of Vaccine Doses Are Independently Associated with the PaO2/FiO2 Ratio on Admission in Hospitalized COVID-19 Patients / Zinellu, Elisabetta; Zinellu, Angelo; Merella, Michela; Mangoni, Arduino A; Pau, Maria Carmina; Fois, Sara S; Fois, Alessandro G; Carru, Ciriaco; Pirina, Pietro. - In: VACCINES. - ISSN 2076-393X. - 10:9(2022), p. 1424. [10.3390/vaccines10091424]

Vaccination Status and Number of Vaccine Doses Are Independently Associated with the PaO2/FiO2 Ratio on Admission in Hospitalized COVID-19 Patients

Zinellu, Elisabetta;Zinellu, Angelo;Pau, Maria Carmina;Fois, Sara S;Fois, Alessandro G;Carru, Ciriaco;Pirina, Pietro
2022-01-01

Abstract

Introduction: Coronavirus Disease-19 (COVID-19) vaccines reduce the risk of severe disease and mortality. However, the association between vaccination status and number of doses and the PaO2/FiO(2) ratio, a clinical measure of hypoxemia associated with an increased risk of intensive care treatment and mortality, has not been investigated. Methods: We retrospectively assessed a consecutive series of 116 patients admitted to hospital with a primary diagnosis of COVID-19 between January and April 2022. Demographic, clinical, and laboratory data were collected within 24 h from admission. Results: There was a significant positive relationship between the number of vaccine doses and the PaO2/FiO(2) ratio (r = 0.223, p = 0.012). This association remained significant after adjusting for confounders. Vaccinated patients had significantly higher PaO2/FiO(2) ratios than the unvaccinated (median: 250; IQR: 195-309 vs. 200; IQR: 156-257, p = 0.013). Conclusion: These results highlight the importance of the number of vaccine doses received in reducing the degree of hypoxia on admission in hospitalized COVID-19 patients.
2022
Vaccination Status and Number of Vaccine Doses Are Independently Associated with the PaO2/FiO2 Ratio on Admission in Hospitalized COVID-19 Patients / Zinellu, Elisabetta; Zinellu, Angelo; Merella, Michela; Mangoni, Arduino A; Pau, Maria Carmina; Fois, Sara S; Fois, Alessandro G; Carru, Ciriaco; Pirina, Pietro. - In: VACCINES. - ISSN 2076-393X. - 10:9(2022), p. 1424. [10.3390/vaccines10091424]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/303740
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