The first general asymmetric synthesis of γ,γ-disubstituted γ-amino acids by copper-catalyzed ring opening of nonstrained lactones with amines is reported. This approach features ample scope, operational simplicity, and wide functional-group diversity. The catalytic process allows access to a series of highly functionalized enantioenriched γ-amino acids featuring quaternary stereocenters with excellent enantiomeric ratios of up to 98:2 and excellent yields of up to 98 %.

Copper-Catalyzed Synthesis of γ-Amino Acids Featuring Quaternary Stereocenters / Gomez, J. E.; Guo, W.; Gaspa, S.; Kleij, A. W.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 56:47(2017), pp. 15035-15038. [10.1002/anie.201709511]

Copper-Catalyzed Synthesis of γ-Amino Acids Featuring Quaternary Stereocenters

Gaspa S.;
2017-01-01

Abstract

The first general asymmetric synthesis of γ,γ-disubstituted γ-amino acids by copper-catalyzed ring opening of nonstrained lactones with amines is reported. This approach features ample scope, operational simplicity, and wide functional-group diversity. The catalytic process allows access to a series of highly functionalized enantioenriched γ-amino acids featuring quaternary stereocenters with excellent enantiomeric ratios of up to 98:2 and excellent yields of up to 98 %.
2017
Copper-Catalyzed Synthesis of γ-Amino Acids Featuring Quaternary Stereocenters / Gomez, J. E.; Guo, W.; Gaspa, S.; Kleij, A. W.. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 56:47(2017), pp. 15035-15038. [10.1002/anie.201709511]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/301888
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