Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heterogeneous landscape of activities. Analysis of transcriptional programs induced in neoplastic cells by distinct classes of epigenetic drugs may foster identification of the most promising agents.

Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy / Anichini, Andrea; Molla, Alessandra; Nicolini, Gabriella; Perotti, Valentina Eleonora; Sgambelluri, Francesco; Covre, Alessia; Fazio, Carolina; Lofiego, Maria Fortunata; Di Giacomo, Anna Maria; Coral, Sandra; Manca, Antonella; Sini, Maria Cristina; Pisano, Marina; Noviello, Teresa; Caruso, Francesca; Brich, Silvia; Pruneri, Giancarlo; Maurichi, Andrea; Santinami, Mario; Ceccarelli, Michele; Palmieri, Giuseppe; Maio, Michele; Mortarini, Roberta. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 41:1(2022). [10.1186/s13046-022-02529-5]

Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

Palmieri, Giuseppe;
2022

Abstract

Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heterogeneous landscape of activities. Analysis of transcriptional programs induced in neoplastic cells by distinct classes of epigenetic drugs may foster identification of the most promising agents.
Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy / Anichini, Andrea; Molla, Alessandra; Nicolini, Gabriella; Perotti, Valentina Eleonora; Sgambelluri, Francesco; Covre, Alessia; Fazio, Carolina; Lofiego, Maria Fortunata; Di Giacomo, Anna Maria; Coral, Sandra; Manca, Antonella; Sini, Maria Cristina; Pisano, Marina; Noviello, Teresa; Caruso, Francesca; Brich, Silvia; Pruneri, Giancarlo; Maurichi, Andrea; Santinami, Mario; Ceccarelli, Michele; Palmieri, Giuseppe; Maio, Michele; Mortarini, Roberta. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 41:1(2022). [10.1186/s13046-022-02529-5]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/298465
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact