Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heterogeneous landscape of activities. Analysis of transcriptional programs induced in neoplastic cells by distinct classes of epigenetic drugs may foster identification of the most promising agents.
Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy / Anichini, Andrea; Molla, Alessandra; Nicolini, Gabriella; Perotti, Valentina Eleonora; Sgambelluri, Francesco; Covre, Alessia; Fazio, Carolina; Lofiego, Maria Fortunata; Di Giacomo, Anna Maria; Coral, Sandra; Manca, Antonella; Sini, Maria Cristina; Pisano, Marina; Noviello, Teresa; Caruso, Francesca; Brich, Silvia; Pruneri, Giancarlo; Maurichi, Andrea; Santinami, Mario; Ceccarelli, Michele; Palmieri, Giuseppe; Maio, Michele; Mortarini, Roberta. - In: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. - ISSN 1756-9966. - 41:1(2022). [10.1186/s13046-022-02529-5]
Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy
Palmieri, Giuseppe;
2022-01-01
Abstract
Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heterogeneous landscape of activities. Analysis of transcriptional programs induced in neoplastic cells by distinct classes of epigenetic drugs may foster identification of the most promising agents.| File | Dimensione | Formato | |
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