BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We therefore aimed to investigate the age-specific impact of infant BCG vaccination on tuberculosis (pulmonary and extrapulmonary) development and mortality.

Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis / Martinez, Leonardo; Cords, Olivia; Liu, Qiao; Acuna-Villaorduna, Carlos; Bonnet, Maryline; Fox, Greg J; Carvalho, Anna Cristina C; Chan, Pei-Chun; Croda, Julio; Hill, Philip C; Lopez-Varela, Elisa; Donkor, Simon; Fielding, Katherine; Graham, Stephen M; Espinal, Marcos A; Kampmann, Beate; Reingold, Arthur; Huerga, Helena; Villalba, Julian A; Grandjean, Louis; Sotgiu, Giovanni; Egere, Uzochukwu; Singh, Sarman; Zhu, Limei; Lienhardt, Christian; Denholm, Justin T; Seddon, James A; Whalen, Christopher C; García-Basteiro, Alberto L; Triasih, Rina; Chen, Cheng; Singh, Jitendra; Huang, Li-Min; Sharma, Surendra; Hannoun, Djohar; Del Corral, Helena; Mandalakas, Anna M; Malone, LaShaunda L; Ling, Du-Lin; Kritski, Afrânio; Stein, Catherine M; Vashishtha, Richa; Boulahbal, Fadila; Fang, Chi-Tai; Boom, W Henry; Netto, Eduardo Martins; Lemos, Antonio Carlos; Hesseling, Anneke C; Kay, Alexander; Jones-López, Edward C; Horsburgh, C Robert; Lange, Christoph; Andrews, Jason R. - In: THE LANCET GLOBAL HEALTH. - ISSN 2214-109X. - 10:9(2022), pp. e1307-e1316. [10.1016/S2214-109X(22)00283-2]

Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis

Sotgiu, Giovanni;
2022

Abstract

BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We therefore aimed to investigate the age-specific impact of infant BCG vaccination on tuberculosis (pulmonary and extrapulmonary) development and mortality.
Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis / Martinez, Leonardo; Cords, Olivia; Liu, Qiao; Acuna-Villaorduna, Carlos; Bonnet, Maryline; Fox, Greg J; Carvalho, Anna Cristina C; Chan, Pei-Chun; Croda, Julio; Hill, Philip C; Lopez-Varela, Elisa; Donkor, Simon; Fielding, Katherine; Graham, Stephen M; Espinal, Marcos A; Kampmann, Beate; Reingold, Arthur; Huerga, Helena; Villalba, Julian A; Grandjean, Louis; Sotgiu, Giovanni; Egere, Uzochukwu; Singh, Sarman; Zhu, Limei; Lienhardt, Christian; Denholm, Justin T; Seddon, James A; Whalen, Christopher C; García-Basteiro, Alberto L; Triasih, Rina; Chen, Cheng; Singh, Jitendra; Huang, Li-Min; Sharma, Surendra; Hannoun, Djohar; Del Corral, Helena; Mandalakas, Anna M; Malone, LaShaunda L; Ling, Du-Lin; Kritski, Afrânio; Stein, Catherine M; Vashishtha, Richa; Boulahbal, Fadila; Fang, Chi-Tai; Boom, W Henry; Netto, Eduardo Martins; Lemos, Antonio Carlos; Hesseling, Anneke C; Kay, Alexander; Jones-López, Edward C; Horsburgh, C Robert; Lange, Christoph; Andrews, Jason R. - In: THE LANCET GLOBAL HEALTH. - ISSN 2214-109X. - 10:9(2022), pp. e1307-e1316. [10.1016/S2214-109X(22)00283-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/295343
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