The etiology of bladder cancer is known to be associated with behavioral and environmental factors. Moreover, several studies suggested a potential role of HPV infection in the pathogenesis with controversial results. A systematic review was conducted to assess the role of HPV. A total of 46 articles that reported the prevalence of HPV infection in squamous (SCC), urothelial (UC), and transitional cell carcinomas (TCC) were selected. A pooled prevalence of 19% was found, with a significant difference in SCC that was mainly driven by HPV-16. Moreover, infection prevalence in case-control studies showed a higher risk of bladder cancer in HPV-positive cases (OR: 7.84; p-value < 0.00001). The results may suggest an etiologic role of HPV in bladder cancer. HPV vaccine administration in both sexes could be key to prevent the infection caused by high-risk genotypes.
Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review / Muresu, Narcisa; Di Lorenzo, Biagio; Saderi, Laura; Sechi, Illari; Del Rio, Arcadia; Piana, Andrea; Sotgiu, Giovanni. - In: DIAGNOSTICS. - ISSN 2075-4418. - 12:7(2022), p. 1759. [10.3390/diagnostics12071759]