: In this study, we characterized the humoral responses in cattle of Sardinia. The animals were divided into three groups: 1) 28 cattle infected with Mycobacterium bovis; 2) 48 cattle from herds in which foci of infection was notified; 3) 50 cattle from herds that were TB-free. Levels of IgG antibody were measured against the following antigens of M. tuberculosis: Heparin-Binding-Haemagglutin (HBHA), Ag85B, PPE44, and PE_PGRS33 to investigate their potential to diagnose TB in animals. Our results indicated that HBHA is a potential candidate for the development of a serological assay for rapid diagnosis of cattle infected with M. bovis.

Heparin binding haemagglutin as potential diagnostic marker of Mycobacterium bovis / Molicotti, Paola; Bua, Alessandra; Ortu, Silvia; Ladu, Maura C; Delogu, Giovanni; Mura, Antonio; Sechi, Leonardo A; Fadda, Giovanni; Zanetti, Stefania. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 31:3(2008), p. 423-7.

Heparin binding haemagglutin as potential diagnostic marker of Mycobacterium bovis

Molicotti, Paola;Bua, Alessandra;Ortu, Silvia;Sechi, Leonardo A;Fadda, Giovanni;Zanetti, Stefania
2008

Abstract

: In this study, we characterized the humoral responses in cattle of Sardinia. The animals were divided into three groups: 1) 28 cattle infected with Mycobacterium bovis; 2) 48 cattle from herds in which foci of infection was notified; 3) 50 cattle from herds that were TB-free. Levels of IgG antibody were measured against the following antigens of M. tuberculosis: Heparin-Binding-Haemagglutin (HBHA), Ag85B, PPE44, and PE_PGRS33 to investigate their potential to diagnose TB in animals. Our results indicated that HBHA is a potential candidate for the development of a serological assay for rapid diagnosis of cattle infected with M. bovis.
Heparin binding haemagglutin as potential diagnostic marker of Mycobacterium bovis / Molicotti, Paola; Bua, Alessandra; Ortu, Silvia; Ladu, Maura C; Delogu, Giovanni; Mura, Antonio; Sechi, Leonardo A; Fadda, Giovanni; Zanetti, Stefania. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 31:3(2008), p. 423-7.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/279978
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