Objectives: The aim of this study was to assess the incidence of being overweight and metabolic syndrome (MS) among people living with HIV (PHIV) in three different cross-sectional studies conducted over three different periods: 2005, 2011 and 2015. Methods: This was a multi-centre, nationwide study. Data were collected in three studies from the CISAI group – SIMOne, HIV-HY and STOPSHIV – and included a total of 3014 PHIV. Logistic regression [odds ratio (OR), 95% confidence interval (CI)] was used to account for age and gender difference among three groups when comparing MS prevalence and being overweight; potential confounders were accounted for by including them in the regression equation. Results: Overall, the mean age was 46.9 ± 10.2 years, and men comprised 73.3% of participants. Comparing 2005, 2011 and 2015, MS was present in 34.5%, 33.0% and 29.3% of PHIV, respectively. Adjusted OR for MS was 0.64 (95% CI: 0.52–0.78) in 2011 and 0.56 (95% CI: 0.46–0.69) in 2015 compared with 2005, while BMI (kg/m2) increased from 23.6 in 2005, 24.5 in 2011 and 24.5 in 2015, with a concomitant increase of being overweight from 29.4% to 39.5% to 39.6% (p < 0.0001). Conclusions: In recent years, PHIV have had a significantly improved metabolic profile compared with previously, despite increasing weight and BMI.

Metabolic syndrome and body weight in people living with HIV infection: analysis of differences observed in three different cohort studies over a decade / Taramasso, L.; Bonfanti, P.; Ricci, E.; Maggi, P.; Orofino, G.; Squillace, N.; Menzaghi, B.; Madeddu, G.; Molteni, C.; Vichi, F.; Riguccini, E.; Saracino, A.; Santoro, C.; Guastavigna, M.; Francisci, D.; Di Biagio, A.; De Socio, G. V.; Sarchi, E.; Chichino, G.; Bolla, C.; Bellacosa, C.; Angarano, G.; Saracino, A.; Calza, L.; Menzaghi, B.; Farinazzo, M.; Angioni, G.; Gussio, M.; Celesia, B. M.; Falasca, K.; Mastroianni, A.; Guadagnino, G.; Vichi, F.; Salomoni, E.; Martinelli, C.; Dentone, C.; Taramasso, L.; Bassetti, M.; Cenderello, G.; Molteni, C.; Pellicano, G. F.; Nunnari, G.; Valsecchi, L.; Cordier, L.; Parisini, S.; Rizzardini, G.; Rusconi, S.; Conti, F.; Bandera, A.; Gori, A.; Motta, D.; Puoti, M.; Migliorino, G. M.; Maggi, P.; Martini, S.; Cascio, A.; Trizzino, M.; Gulminetti, R.; Nofri, M.; Francisci, D.; Cibelli, D.; Parruti, G.; Madeddu, G.; Mameli, M. S.; Orofino, G.; Guastavigna, M.. - In: HIV MEDICINE. - ISSN 1464-2662. - 23:1(2022), pp. 70-79. [10.1111/hiv.13165]

Metabolic syndrome and body weight in people living with HIV infection: analysis of differences observed in three different cohort studies over a decade

Maggi P.;Orofino G.;Madeddu G.;Saracino A.;Saracino A.;Maggi P.;Madeddu G.;Mameli M. S.;Orofino G.;
2022-01-01

Abstract

Objectives: The aim of this study was to assess the incidence of being overweight and metabolic syndrome (MS) among people living with HIV (PHIV) in three different cross-sectional studies conducted over three different periods: 2005, 2011 and 2015. Methods: This was a multi-centre, nationwide study. Data were collected in three studies from the CISAI group – SIMOne, HIV-HY and STOPSHIV – and included a total of 3014 PHIV. Logistic regression [odds ratio (OR), 95% confidence interval (CI)] was used to account for age and gender difference among three groups when comparing MS prevalence and being overweight; potential confounders were accounted for by including them in the regression equation. Results: Overall, the mean age was 46.9 ± 10.2 years, and men comprised 73.3% of participants. Comparing 2005, 2011 and 2015, MS was present in 34.5%, 33.0% and 29.3% of PHIV, respectively. Adjusted OR for MS was 0.64 (95% CI: 0.52–0.78) in 2011 and 0.56 (95% CI: 0.46–0.69) in 2015 compared with 2005, while BMI (kg/m2) increased from 23.6 in 2005, 24.5 in 2011 and 24.5 in 2015, with a concomitant increase of being overweight from 29.4% to 39.5% to 39.6% (p < 0.0001). Conclusions: In recent years, PHIV have had a significantly improved metabolic profile compared with previously, despite increasing weight and BMI.
2022
Metabolic syndrome and body weight in people living with HIV infection: analysis of differences observed in three different cohort studies over a decade / Taramasso, L.; Bonfanti, P.; Ricci, E.; Maggi, P.; Orofino, G.; Squillace, N.; Menzaghi, B.; Madeddu, G.; Molteni, C.; Vichi, F.; Riguccini, E.; Saracino, A.; Santoro, C.; Guastavigna, M.; Francisci, D.; Di Biagio, A.; De Socio, G. V.; Sarchi, E.; Chichino, G.; Bolla, C.; Bellacosa, C.; Angarano, G.; Saracino, A.; Calza, L.; Menzaghi, B.; Farinazzo, M.; Angioni, G.; Gussio, M.; Celesia, B. M.; Falasca, K.; Mastroianni, A.; Guadagnino, G.; Vichi, F.; Salomoni, E.; Martinelli, C.; Dentone, C.; Taramasso, L.; Bassetti, M.; Cenderello, G.; Molteni, C.; Pellicano, G. F.; Nunnari, G.; Valsecchi, L.; Cordier, L.; Parisini, S.; Rizzardini, G.; Rusconi, S.; Conti, F.; Bandera, A.; Gori, A.; Motta, D.; Puoti, M.; Migliorino, G. M.; Maggi, P.; Martini, S.; Cascio, A.; Trizzino, M.; Gulminetti, R.; Nofri, M.; Francisci, D.; Cibelli, D.; Parruti, G.; Madeddu, G.; Mameli, M. S.; Orofino, G.; Guastavigna, M.. - In: HIV MEDICINE. - ISSN 1464-2662. - 23:1(2022), pp. 70-79. [10.1111/hiv.13165]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/278278
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