High levels of plasma chitotriosidase (Chit) represents a marker of macrophage activation in human malaria infection.Plasmodium falciparumduring its maturation cycle in theAnophelesmidgut produces an analogue of Chit for the digestion of peritrophic matrix (PM). Our results confirm the hypothesis that Chit contained in blood of malaria patients could helpP. falciparumto complete its cycle in theAnophelesmidgut and to produce a bigger number of oocysts/sporozoites. This could balance the different genetic protection in humans conferred by the heterozygous Hb beta (S) gene, which seems to be associated with an increasing effect onP. falciparumtransmission from humans to mosquitoes.
Human chitotriosidase helpsPlasmodium falciparumin theAnophelesmidgut / Di Luca, Marco; Romi, Roberto; Severini, Francesco; Toma, Lucio; Musumeci, Marco; Fausto, Anna Maria; Mazzini, Massimo; Gambellini, Gabriella; Musumeci, Salvatore. - In: JOURNAL OF VECTOR BORNE DISEASES. - ISSN 0972-9062. - 43:3(2006), pp. 144-146.
Human chitotriosidase helpsPlasmodium falciparumin theAnophelesmidgut
Musumeci, Salvatore
2006-01-01
Abstract
High levels of plasma chitotriosidase (Chit) represents a marker of macrophage activation in human malaria infection.Plasmodium falciparumduring its maturation cycle in theAnophelesmidgut produces an analogue of Chit for the digestion of peritrophic matrix (PM). Our results confirm the hypothesis that Chit contained in blood of malaria patients could helpP. falciparumto complete its cycle in theAnophelesmidgut and to produce a bigger number of oocysts/sporozoites. This could balance the different genetic protection in humans conferred by the heterozygous Hb beta (S) gene, which seems to be associated with an increasing effect onP. falciparumtransmission from humans to mosquitoes.| File | Dimensione | Formato | |
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