BackgroundV. choleraeis the etiological agent of cholera, a major public health concern in most developing countries. Virulence ofV. choleraerelies on the powerful cholera toxin, encoded by the CTX prophage. The emergence of new pathogenic variants in the recent years has been mostly associated with new CTX prophage rearrangements.ResultsIn this retrospective study, we show that the epidemicV. choleraeO1 El Tor strain responsible for the 2006 outbreak in Angola is clonally and genetically different from El Tor strains circulating in the 1990s in the same area. Strains from 2006 carry ICEVchAng3 of the SXT/R391 family. This ICE is associated with a narrower multidrug resistance profile compared to the one conferred by plasmid p3iANG to strains of the 1990s. The CTX prophage carried by 2006 El Tor strains is characterized byrstRETandctxBClaalleles organized in a RS1-RS2-Core array on chromosome I. Interestingly, the newly emerging atypical strain belongs to a clade previously known to comprise only clinical isolates from the Indian subcontinent that also contain the same ICE of the SXT/R391 family.ConclusionsOur findings remark the appearance of a novelV. choleraeepidemic variant in Africa with a new CTXΦ arrangement previously described only in the Indian Subcontinent.

NewV. choleraeatypical El Tor variant emerged during the 2006 epidemic outbreak in Angola / Cappuccinelli, Pietro Antonio. - 11:130(2011), pp. 1-8. [10.1186/1471-2180-11-130]

NewV. choleraeatypical El Tor variant emerged during the 2006 epidemic outbreak in Angola

Cappuccinelli, Pietro Antonio;Bacciu, Donatella;Colombo, Mauro Maria;
2011

Abstract

BackgroundV. choleraeis the etiological agent of cholera, a major public health concern in most developing countries. Virulence ofV. choleraerelies on the powerful cholera toxin, encoded by the CTX prophage. The emergence of new pathogenic variants in the recent years has been mostly associated with new CTX prophage rearrangements.ResultsIn this retrospective study, we show that the epidemicV. choleraeO1 El Tor strain responsible for the 2006 outbreak in Angola is clonally and genetically different from El Tor strains circulating in the 1990s in the same area. Strains from 2006 carry ICEVchAng3 of the SXT/R391 family. This ICE is associated with a narrower multidrug resistance profile compared to the one conferred by plasmid p3iANG to strains of the 1990s. The CTX prophage carried by 2006 El Tor strains is characterized byrstRETandctxBClaalleles organized in a RS1-RS2-Core array on chromosome I. Interestingly, the newly emerging atypical strain belongs to a clade previously known to comprise only clinical isolates from the Indian subcontinent that also contain the same ICE of the SXT/R391 family.ConclusionsOur findings remark the appearance of a novelV. choleraeepidemic variant in Africa with a new CTXΦ arrangement previously described only in the Indian Subcontinent.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/264745
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