In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, a new tricycle, the tetrahydropyrrolo[1,2-a]indole-1,8-dione, has been synthesized by an intramolecular Friedel-Crafts acylation, as a synthon suitable to be functionalized to give novel compounds with potential biological properties. Also, an unusual nucleophilic α-addition to methyl propiolate by 1,5,6,7-tetrahydro-4H-indol-4-one was observed and discussed.
Synthesis of pyrrolo[1,2-a]indole-1,8(5H)-diones as new synthons for developing novel tricyclic compounds of pharmaceutical interest / Sechi, Mario; Sannia, Luciano; Orecchioni, Maria; Mura, Alessio; Paglietti, Giuseppe. - 2004:Part 5(2004), pp. 97-106.
Synthesis of pyrrolo[1,2-a]indole-1,8(5H)-diones as new synthons for developing novel tricyclic compounds of pharmaceutical interest
Sechi, Mario;Orecchioni, Maria;Mura, Alessio;Paglietti, Giuseppe
2004-01-01
Abstract
In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, a new tricycle, the tetrahydropyrrolo[1,2-a]indole-1,8-dione, has been synthesized by an intramolecular Friedel-Crafts acylation, as a synthon suitable to be functionalized to give novel compounds with potential biological properties. Also, an unusual nucleophilic α-addition to methyl propiolate by 1,5,6,7-tetrahydro-4H-indol-4-one was observed and discussed.| File | Dimensione | Formato | |
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