Some 6-ethyl-1(2)(3)-R-1(2)(3)H-triazolo[4,5-f]quinolin-9-one-8-carboxylic acids were prepared as novel analogues of oxolinic acid in order to evaluate the effect on antibacterial activity of the isosteric replacement of the dioxolic moiety with the triazole ring substituted in position 1 or 2. In vitro tests showed a good and selective activity against Escherichia coli (MIC 12.5 micrograms/ml) of compound (XVI).
1,2,3-triazolo[4,5-f]quinolines: II: preparation and antimicrobial evaluation of 6-ethyl-6,9-dihydro-1(2)(3)-R-1(2) (3)H-triazolo [4,5-f]quinolin-9-one-8-carboxylic acids as anti-infectives of the urinary tract / Cappuccinelli, Pietro Antonio; Nuvole, Antonio Michele; Sanna, Paolo Antonio; Paglietti, Giuseppe; Zanetti, Stefania Anna Lucia; Juliano, Claudia Clelia Assunta. - In: IL FARMACO. - ISSN 0014-827X. - 44:6(1989), pp. 619-632.
1,2,3-triazolo[4,5-f]quinolines: II: preparation and antimicrobial evaluation of 6-ethyl-6,9-dihydro-1(2)(3)-R-1(2) (3)H-triazolo [4,5-f]quinolin-9-one-8-carboxylic acids as anti-infectives of the urinary tract
Cappuccinelli, Pietro Antonio;Nuvole, Antonio Michele;Paglietti, Giuseppe;Zanetti, Stefania Anna Lucia;Juliano, Claudia Clelia Assunta
1989-01-01
Abstract
Some 6-ethyl-1(2)(3)-R-1(2)(3)H-triazolo[4,5-f]quinolin-9-one-8-carboxylic acids were prepared as novel analogues of oxolinic acid in order to evaluate the effect on antibacterial activity of the isosteric replacement of the dioxolic moiety with the triazole ring substituted in position 1 or 2. In vitro tests showed a good and selective activity against Escherichia coli (MIC 12.5 micrograms/ml) of compound (XVI).| File | Dimensione | Formato | |
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