The reactions of the tridentate hydrazone ligand,N’-[1-(pyridin-2-yl)ethylidene]acetohydrazide (HL), obtained by condensation of 2-acetylpyridine with acetic hyadrazide, with copper nitrate trihydrate in the presence of thiocyanate, or with CuCl2produce two distinct coordination compounds, namely a one-dimensional helical coordination chain of [CuL(NCS)]n(1) units, and a doubly chlorido-bridged dinuclear complex [Cu2L2Cl2] (2) (where L=CH3C(O)=N − N=CCH3C5H4N). Single-crystal X-ray structural determination studies reveal that in complex1, a deprotonated hydrazone ligand L-coordinates a copper(II) ion that is bridged to two neighbouring metal centres by SCN-anions, generating a one-dimensional helical coordination chain. In complex2, two symmetry-related, adjacent copper(II) coordination entities are doubly chlorido-bridged, producing a dicopper entity with a Cu···Cu distance of 3.402 (1). The two coordination compounds have been fully characterised by elemental analysis, spectroscopic techniques including IR, UV– vis and electron paramagnetic resonance, and variable-temperature magnetic studies. The biological effects of1and2on the viability of human colorectal carcinoma cells (COLO-205 and HT-29) were evaluated using an MTT assay, and the results indicate that these complexes induce a decrease in cell-population growth of human colorectal carcinoma cells with apoptosis.
End-to-end thiocyanato-bridged helical chain polymer and dichlorido-bridged copper(II) complexes with a hydrazone ligand: synthesis, characterisation by electron paramagnetic resonance and variable- temperature magnetic studies, and inhibitory effects on human colorectal carcinoma cells / Garribba, Eugenio; Das, Kuheli; Sinha, Chittaranjan; Huang, Jui-Hsien; Hsu, Chin-Lin; Datta, Amitabha; Hsiao, Ching-Sheng. - 1:2(2012), pp. 80-89. [10.1002/open.201100011]
End-to-end thiocyanato-bridged helical chain polymer and dichlorido-bridged copper(II) complexes with a hydrazone ligand: synthesis, characterisation by electron paramagnetic resonance and variable- temperature magnetic studies, and inhibitory effects on human colorectal carcinoma cells
Garribba, Eugenio;
2012-01-01
Abstract
The reactions of the tridentate hydrazone ligand,N’-[1-(pyridin-2-yl)ethylidene]acetohydrazide (HL), obtained by condensation of 2-acetylpyridine with acetic hyadrazide, with copper nitrate trihydrate in the presence of thiocyanate, or with CuCl2produce two distinct coordination compounds, namely a one-dimensional helical coordination chain of [CuL(NCS)]n(1) units, and a doubly chlorido-bridged dinuclear complex [Cu2L2Cl2] (2) (where L=CH3C(O)=N − N=CCH3C5H4N). Single-crystal X-ray structural determination studies reveal that in complex1, a deprotonated hydrazone ligand L-coordinates a copper(II) ion that is bridged to two neighbouring metal centres by SCN-anions, generating a one-dimensional helical coordination chain. In complex2, two symmetry-related, adjacent copper(II) coordination entities are doubly chlorido-bridged, producing a dicopper entity with a Cu···Cu distance of 3.402 (1). The two coordination compounds have been fully characterised by elemental analysis, spectroscopic techniques including IR, UV– vis and electron paramagnetic resonance, and variable-temperature magnetic studies. The biological effects of1and2on the viability of human colorectal carcinoma cells (COLO-205 and HT-29) were evaluated using an MTT assay, and the results indicate that these complexes induce a decrease in cell-population growth of human colorectal carcinoma cells with apoptosis.File | Dimensione | Formato | |
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