Background:Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of communitydwelling middle-aged and older adults.Methods:Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55–85 years) randomly selected from the Hunter Community Study.Results:Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78–1.33 mmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31–0.44) to 3.08 (90% CI 2.45–3.76) mmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial =20.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial =20.13; P = 0.0063).Conclusions:A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of communitydwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.

Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults / Sotgia, Salvatore; Zinellu, Angelo; Mangoni, Arduino A.; Pintus, Gianfranco; Attia, John; Carru, Ciriaco; Mcevoy, Mark. - In: PLOS ONE. - ISSN 1932-6203. - 9:1(2014). [10.1371/journal.pone.0084918]

Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults

Sotgia, Salvatore
;
Zinellu, Angelo;Pintus, Gianfranco;Carru, Ciriaco;
2014-01-01

Abstract

Background:Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of communitydwelling middle-aged and older adults.Methods:Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55–85 years) randomly selected from the Hunter Community Study.Results:Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78–1.33 mmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31–0.44) to 3.08 (90% CI 2.45–3.76) mmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial =20.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial =20.13; P = 0.0063).Conclusions:A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of communitydwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.
2014
Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults / Sotgia, Salvatore; Zinellu, Angelo; Mangoni, Arduino A.; Pintus, Gianfranco; Attia, John; Carru, Ciriaco; Mcevoy, Mark. - In: PLOS ONE. - ISSN 1932-6203. - 9:1(2014). [10.1371/journal.pone.0084918]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/264210
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