Some 4-ethyl-1(2)-R-1(2)H-4,7-dihydro-triazolo[4,5-h]-quinolin-7-one-6- carboxylic acids were prepared as novel analogues of oxolinic acid, in order to discover the influence of the annelation position of the triazole ring on the antimicrobial activity that, in some isomers triazolo[4,5-f]quinoline carboxylic acids, is selective against Escherichia coli. Some interesting side reactions in the cyclization of 1(2)-R-1(2)H-benzotriazol-4-yl-aminomethylenemalonate are also described. The biological results indicate that this type of annelation is not profitable for antimicrobial activity.

1,2,3-triazolo[4,5-h]quinolines: III: preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract / Carta, Antonio. - In: IL FARMACO. - ISSN 0014-827X. - 47:7-8(1992), pp. 1001-1019.

1,2,3-triazolo[4,5-h]quinolines: III: preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract

Paglietti, Giuseppe;Zanetti, Stefania Anna Lucia;Fadda, Giovanni;Carta, Antonio;
1992

Abstract

Some 4-ethyl-1(2)-R-1(2)H-4,7-dihydro-triazolo[4,5-h]-quinolin-7-one-6- carboxylic acids were prepared as novel analogues of oxolinic acid, in order to discover the influence of the annelation position of the triazole ring on the antimicrobial activity that, in some isomers triazolo[4,5-f]quinoline carboxylic acids, is selective against Escherichia coli. Some interesting side reactions in the cyclization of 1(2)-R-1(2)H-benzotriazol-4-yl-aminomethylenemalonate are also described. The biological results indicate that this type of annelation is not profitable for antimicrobial activity.
1,2,3-triazolo[4,5-h]quinolines: III: preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract / Carta, Antonio. - In: IL FARMACO. - ISSN 0014-827X. - 47:7-8(1992), pp. 1001-1019.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/263476
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